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Review
. 2022 Apr 13:9:863238.
doi: 10.3389/fcvm.2022.863238. eCollection 2022.

Cardiac Remodeling After Myocardial Infarction: Functional Contribution of microRNAs to Inflammation and Fibrosis

Fahimeh Varzideh  1   2 , Urna Kansakar  1   2 , Kwame Donkor  1 , Scott Wilson  1 , Stanislovas S Jankauskas  1   2 , Pasquale Mone  1 , Xujun Wang  1   2 , Angela Lombardi  1 , Gaetano Santulli  1   2
Affiliations
Review

Cardiac Remodeling After Myocardial Infarction: Functional Contribution of microRNAs to Inflammation and Fibrosis

Fahimeh Varzideh et al. Front Cardiovasc Med. .

Abstract

After an ischemic injury, the heart undergoes a complex process of structural and functional remodeling that involves several steps, including inflammatory and fibrotic responses. In this review, we are focusing on the contribution of microRNAs in the regulation of inflammation and fibrosis after myocardial infarction. We summarize the most updated studies exploring the interactions between microRNAs and key regulators of inflammation and fibroblast activation and we discuss the recent discoveries, including clinical applications, in these rapidly advancing fields.

Keywords: cardiac remodeling; clinical trials; drug development; epigenetics; heart failure; ischemic heart disease; non-coding RNA; oxidative stress.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Schematic representation of miRNA-based drug development. Adenovirus, adeno-associated virus (AAV), lentivirus particles, and liposomes are used to deliver miRNA mimics or antimiRs; miRNAs are investigated in vitro, in vivo, and ex vivo models to develop next-generation therapeutics for cardiovascular diseases. CMs, cardiomyocytes; EHTs, engineered heart tissues; hiPSCs, human induced pluripotent stem cells; I/R, ischemia-reperfusion; MI, myocardial infarction; TAC, transverse aortic constriction.
See this image and copyright information in PMC

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