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Review
. 2022 Apr 19:2022:9612296.
doi: 10.1155/2022/9612296. eCollection 2022.

Simulation of Mechanical Heart Valve Dysfunction and the Non-Newtonian Blood Model Approach

Aolin Chen  1 , Adi Azriff Bin Basri  1 , Norzian Bin Ismail  2 , Masaaki Tamagawa  3 , Di Zhu  1 , Kamarul Arifin Ahmad  1
Affiliations
Review

Simulation of Mechanical Heart Valve Dysfunction and the Non-Newtonian Blood Model Approach

Aolin Chen et al. Appl Bionics Biomech. .

Retraction in

Abstract

The mechanical heart valve (MHV) is commonly used for the treatment of cardiovascular diseases. Nonphysiological hemodynamic in the MHV may cause hemolysis, platelet activation, and an increased risk of thromboembolism. Thromboembolism may cause severe complications and valve dysfunction. This paper thoroughly reviewed the simulation of physical quantities (velocity distribution, vortex formation, and shear stress) in healthy and dysfunctional MHV and reviewed the non-Newtonian blood flow characteristics in MHV. In the MHV numerical study, the dysfunction will affect the simulation results, increase the pressure gradient and shear stress, and change the blood flow patterns, increasing the risks of hemolysis and platelet activation. The blood flow passes downstream and has obvious recirculation and stagnation region with the increased dysfunction severity. Due to the complex structure of the MHV, the non-Newtonian shear-thinning viscosity blood characteristics become apparent in MHV simulations. The comparative study between Newtonian and non-Newtonian always shows the difference. The shear-thinning blood viscosity model is the basics to build the blood, also the blood exhibiting viscoelastic properties. More details are needed to establish a complete and more realistic simulation.

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Conflict of interest statement

The authors declared that they have no conflicts of interest regarding this work.

Figures

Figure 1
Figure 1
BMHV structure and computational domain [36].
Figure 2
Figure 2
Coherent structure downstream of a normal and a defective mechanical valve for 7 L/min [25].
Figure 3
Figure 3
Flow patterns through a dysfunctional BMHV at peak systolic (0.1 s) and early deceleration phase (0.3 s): (a) velocity magnitude, (b) vorticity, and (c) turbulent shear stress [6].
Figure 4
Figure 4
Vorticity distributions and coherent structure downstream of a healthy and a dysfunctional mechanical valve at different time instants [34].
See this image and copyright information in PMC

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