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Case Reports
. 2022 Apr 26;10(4):e05681.
doi: 10.1002/ccr3.5681. eCollection 2022 Apr.

Catheter-directed thrombolysis for massive deep vein thrombosis in an adolescent with severe antithrombin deficiency

Søren Thorgaard Bønløkke  1   2 , Maria Arvad Serifi  3 , Torben Stamm Mikkelsen  2   4 , Anne-Mette Hvas  1   2
Affiliations
Case Reports

Catheter-directed thrombolysis for massive deep vein thrombosis in an adolescent with severe antithrombin deficiency

Søren Thorgaard Bønløkke et al. Clin Case Rep. .

Abstract

In this case report we describe a case of massive deep vein thrombosis in an adolescent. The case was complicated by severe antithrombin deficiency caused by a previously unreported mutation. We discuss the use of catheter directed thrombolysis and (F)Xa inhibitors in children and adolescents.

Keywords: cardiovascular disorders; hematology; pediatrics and adolescent medicine.

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Conflict of interest statement

STB has no conflicts regarding the present manuscript but has received research funding from CSL Behring. AMH has no conflicts of interest regarding the present work but has the following general conflicts of interest: speaker fees from CSL Behring, Bayer, Boehringer‐Ingelheim, Bristol‐Myers Squibb, and Astellas and unrestricted research support from CSL Behring and Octapharma. The remaining authors have no conflicts of interests to declare.

Figures

FIGURE 1
FIGURE 1
(A and B) Right and left side venography prior to thrombolysis showing no contrast flow in the femoral veins. (C) Post thrombolysis venography. White arrow shows extensive collateral formation. Blue arrow: Vena cava hypoplasia/agenesis
FIGURE 2
FIGURE 2
Axial balanced fast field echo (BFFE) MRI images at L2/L3 level above the iliac bifurcation. Blue arrow points to the atretic vena cava inferior with no flow. Orange arrow points to the dilated right ovarian vein, left ovarian vein is also prominent because of the collateral venous flow
See this image and copyright information in PMC

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