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. 2022 Feb 14;15(5):999-1006.
doi: 10.1093/ckj/sfac045. eCollection 2022 May.

Middle-term outcomes in renal transplant recipients with COVID-19: a national, multicenter, controlled study

Ozgur Akin Oto  1 , Savas Ozturk  1 , Mustafa Arici  2 , Arzu Velioğlu  3 , Belda Dursun  4 , Nurana Guller  1 , İdris Şahin  5 , Zeynep Ebru Eser  6 , Saime Paydaş  7 , Sinan Trabulus  8 , Sümeyra Koyuncu  9 , Murathan Uyar  10 , Zeynep Ural  11 , Rezzan Eren Sadioğlu  12 , Hamad Dheir  13 , Neriman Sıla Koç  2 , Hakan Özer  14 , Beyza Algül Durak  15 , Cuma Bülent Gül  16 , Umut Kasapoğlu  17 , Ebru Gök Oğuz  18 , Mehmet Tanrısev  19 , Gülşah Şaşak Kuzgun  20 , Safak Mirioglu  21 , Erkan Dervişoğlu  22 , Ertuğrul Erken  23 , Numan Görgülü  24 , Sultan Özkurt  25 , Zeki Aydın  26 , İlhan Kurultak  27 , Melike Betül Öğütmen  28 , Serkan Bakırdöğen  29 , Burcu Kaya  3 , Serhat Karadağ  30 , Memnune Sena Ulu  31 , Özkan Güngör  23 , Elif Arı Bakır  32 , Ali Rıza Odabaş  33 , Nurhan Seyahi  8 , Alaattin Yıldız  1 , Kenan Ateş  12
Affiliations

Middle-term outcomes in renal transplant recipients with COVID-19: a national, multicenter, controlled study

Ozgur Akin Oto et al. Clin Kidney J. .

Abstract

Background: In this study, we evaluated 3-month clinical outcomes of kidney transplant recipients (KTR) recovering from COVID-19 and compared them with a control group.

Method: The primary endpoint was death in the third month. Secondary endpoints were ongoing respiratory symptoms, need for home oxygen therapy, rehospitalization for any reason, lower respiratory tract infection, urinary tract infection, biopsy-proven acute rejection, venous/arterial thromboembolic event, cytomegalovirus (CMV) infection/disease and BK viruria/viremia at 3 months.

Results: A total of 944 KTR from 29 different centers were included in this study (523 patients in the COVID-19 group; 421 patients in the control group). The mean age was 46 ± 12 years (interquartile range 37-55) and 532 (56.4%) of them were male. Total number of deaths was 8 [7 (1.3%) in COVID-19 group, 1 (0.2%) in control group; P = 0.082]. The proportion of patients with ongoing respiratory symptoms [43 (8.2%) versus 4 (1.0%); P < 0.001] was statistically significantly higher in the COVID-19 group compared with the control group. There was no significant difference between the two groups in terms of other secondary endpoints.

Conclusion: The prevalence of ongoing respiratory symptoms increased in the first 3 months post-COVID in KTRs who have recovered from COVID-19, but mortality was not significantly different.

Keywords: COVID-19; kidney transplantation; mortality; outcome; registry.

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Figures

Graphical Abstract
Graphical Abstract
FIGURE 1:
FIGURE 1:
Flowchart of the study. KTR, kidney transplant recipient; RT-PCR, reverse transcriptase-polymerase chain reaction.
See this image and copyright information in PMC

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