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. 2022 Apr;27(2):13596535211067600.
doi: 10.1177/13596535211067600.

Tenofovir alafenamide fumarate

William A Lee  1 , Andrew K Cheng  2
Affiliations
Free article

Tenofovir alafenamide fumarate

William A Lee et al. Antivir Ther. 2022 Apr.
Free article

Abstract

Tenofovir alafenamide fumarate is a lipophilic prodrug of tenofovir which is preferentially metabolized in lymphatic tissue resulting in high concentrations of tenofovir (TFV) and its active diphosphate metabolite inside the cells that replicate HIV. Due to its selectivity for these tissues, lower total doses of TAF can be administered relative to tenofovir disoproxil fumarate (TDF) which results in improved bone and renal biomarkers. Tenofovir alafenamide fumarate has become the "backbone" of multiple combination products for the treatment of HIV, combined with emtricitabine for PreP and as a monotherapy for the treatment or HBV.

Keywords: HBV; HIV; PrEP; nucleoside; nucleotide; tenofovir; tenofovir alafenamide fumarate.

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