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Review
. 2022 Jul;59(7):4223-4241.
doi: 10.1007/s12035-022-02847-x. Epub 2022 May 2.

The Role of TDP-43 in Neurodegenerative Disease

Yan-Zhe Liao #  1 , Jing Ma #  2 , Jie-Zhi Dou  3
Affiliations
Review

The Role of TDP-43 in Neurodegenerative Disease

Yan-Zhe Liao et al. Mol Neurobiol. 2022 Jul.

Abstract

In recent years, more and more neurodegenerative diseases, such as ALS, FTLD and AD, have been found to share a common pathological feature, which is the depletion of TDP-43 in the nucleus and the accumulation of TDP-43 in the cytoplasm through hyperphosphorylation, ubiquitination and cleavage. Therefore, this kind of neurodegenerative disease is also called TDP-43 proteinopathy. This suggests that TDP-43 plays a role in the pathogenesis of disease. Current studies show that the pathophysiological mechanism of TDP-43 in neurodegeneration is very complex. In this review, we describe the structure of TDP-43, its main physiological functions, the possible pathogenesis and how TDP-43 provides a new pathway to treat neurodegenerative diseases.

Keywords: Neurodegenerative disease; TDP-43; TDP-43 proteinopathy.

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References

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