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Case Reports
. 2022 Aug;63(3):380-384.
doi: 10.1111/ajd.13849. Epub 2022 May 2.

Importance of histopathological analysis and molecular genetics in a rare neonatal case of rhabdomyosarcoma

Prudence Gramp  1 , Tania Zappala  2 , Lena Von Schuckmann  3 , Diane Payton  4 , Laura Wheller  3
Affiliations
Case Reports

Importance of histopathological analysis and molecular genetics in a rare neonatal case of rhabdomyosarcoma

Prudence Gramp et al. Australas J Dermatol. 2022 Aug.

Abstract

We present a case of a neonate who presented with multiple cutaneous and subcutaneous nodules, which was found to be metastatic embryonal rhabdomyosarcoma. Rhabdomyosarcoma is a soft tissue malignancy that usually occurs in children aged one to five but is rare in neonates. The histopathological analysis and molecular genetics are important in the classification of subtype and in guiding treatment options and informing prognosis.

Keywords: child; dermatology; rhabdomyosarcoma.

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Conflict of interest statement

The authors declares that there is no conflict of interest.

Figures

FIGURE 1
FIGURE 1
(a) Nodules on the abdomen. (b) Nodules on the scalp
FIGURE 2
FIGURE 2
(a) (H&E x2): Full thickness dermal infiltrate of small tumour cells. (b) (H&E x10): Infiltrate between dermal collagen with sparing of adnexa. (c) (H&E x 40): Poorly differentiated tumour cells with hyperchromatic nuclei, ill‐defined minimal cytoplasm, mitoses and karyorrhexis. (d,e,f) (desmin, myogenin and MYOD1) positive in tumour cells
FIGURE 3
FIGURE 3
MRI imaging showing disseminated disease throughout the legs and abdomen
See this image and copyright information in PMC

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