COVID-19 and hairy-cell leukemia: an EPICOVIDEHA survey

Sylvain Lamure¹, Jon Salmanton-García^{2

3}, Elena Robin-Marieton⁴, Ozren Jaksic⁵, Milena Kohn⁴, Francesco Marchesi⁶, Monia Marchetti⁷, Shaimaa El-Ashwah⁸, Fatih Demirkan⁹, Toni Valković¹⁰, Noemí Fernández¹¹, Maria Chiara Tisi¹², Zlate Stojanoski¹³, Guldane Cengiz Seval¹⁴, Osman Ilhan¹⁴, Lucia Prezioso¹⁵, Maria Merelli¹⁶, Alberto López-García¹⁷, Marie-Pierre Ledoux¹⁸, Austin Kulasekararaj¹⁹, Tomás-José González-López²⁰, Maria Gomes da Silva²¹, Ziad Emarah⁸, Rafael F Duarte²², Chiara Cattaneo²³, Ola Blennow²⁴, Yavuz M Bilgin²⁵, Rui Bergantim²⁶, Josip Batinić²⁷, Raul Cordoba²⁸, Jenna Essame¹⁹, Anna Nordlander²⁴, Raquel Nunes Rodrigues²¹, Maria Vittoria Sacchi⁷, Sofia Zompi²⁹, Alessandro Busca²⁹, Paolo Corradini³⁰, Martin Hoenigl³¹, Nikolai Klimko³², Philipp Koehler^{2

3}, Antonio Pagliuca³³, Francesco Passamonti³⁴, Rémy Duléry³⁵, Oliver A Cornely^{36

37

38

39

40}, Caroline Besson⁴¹, Livio Pagano⁴²

Affiliations

¹ Department of Clinical Hematology, Montpellier University Hospital, IGMM UMR5535 Centre National de la Recherche Scientifique (CNRS), University of Montpellier, Montpellier, France.
² Faculty of Medicine and University Hospital Cologne, Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
³ Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD) and Excellence Center for Medical Mycology (ECMM), University of Cologne, Cologne, Germany.
⁴ Service d'Hématologie Oncologie, Centre Hospitalier de Versailles, Le Chesnay, France.
⁵ University Hospital Dubrava, Zagreb, Croatia.
⁶ Hematology and Stem Cell Transplant Unit, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Regina Elena National Cancer Institute, Rome, Italy.
⁷ Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
⁸ Oncology Center, Mansoura University, Mansoura, Egypt.
⁹ Division of Hematology, Dokuz Eylul University, Izmir, Turkey.
¹⁰ University Hospital Centre Rijeka, and Croatian Cooperative Group for Hematological Diseases (CROHEM), Faculty of Medicine and Faculty of Health Studies University of Rijeka, Rijeka, Croatia.
¹¹ Hospital Universitario Marqués de Valdecilla, Santander, Spain.
¹² Department of Hematology, Ospedale San Bortolo, Vicenza, Italy.
¹³ University Clinic of Hematology, Skopje, Republic of North Macedonia.
¹⁴ Department of Hematology, Ankara University School of Medicine, Ankara, Turkey.
¹⁵ Hematology and Bone Marrow Unit, University of Parma Hospital, Parma, Italy.
¹⁶ Azienda Sanitaria Universitaria del Friuli Centrale, Udine, Italy.
¹⁷ Fundacion Jimenez Diaz University Hospital, Health Research Institute IIS-FJD, Madrid, Spain.
¹⁸ Institut de Cancérologie de Strasbourg Europe, Strasbourg, France.
¹⁹ King's College Hospital, London, United Kingdom.
²⁰ Department of Hematology, Hospital Universitario de Burgos, Burgos, Spain.
²¹ Departamento de Hematologia, Instituto Português de Oncologia, Lisboa, Portugal.
²² Hospital Universitario Puerta de Hierro, Majadahonda, Spain.
²³ Hematology Unit, ASST-Spedali Civili, Brescia, Italy.
²⁴ Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden.
²⁵ Department of Internal Medicine, Adrz, Goes, The Netherlands.
²⁶ Centro Hospitalar e Universitário São João, Porto, Portugal.
²⁷ School of Medicine, University of Zagreb, and Croatian Cooperative Group for Hematological Diseases (CROHEM), Zagreb, Croatia.
²⁸ Health Research Institute IIS-FJD, Fundacion Jimenez Diaz University Hospital, Madrid, Spain.
²⁹ Stem Cell Transplant Center, AOU Citta' della Salute e della Scienza, Turin, Italy.
³⁰ University of Milan and Fondazione IRCCS, Istituto Nazionale dei Tumori, Milan, Italy.
³¹ Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, San Diego, and Clinical and Translational Fungal Research-Working Group, University of California San Diego, La Jolla, CA, and Division of Infectious Diseases, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
³² North-Western State Medical University named after Iliá Ilich Méchnikov, Saint-Petersburg, Russia.
³³ Department of Hematological Medicine, Kings College Hospital NHS Foundation Trust, London, United Kingdom.
³⁴ Department of Medicine and Surgery, University of Insubria and ASST Sette Laghi, Ospedale di Circolo of Varese, Varese, Italy.
³⁵ Service d'Hématologie Clinique et de Thérapie Cellulaire, Hôpital Saint Antoine, Assistance Publique-Hôpitaux de Paris, Sorbonne University, INSERM UMRS 938, Paris, France, Faculty of Medicine, University of Cologne, and Department I of Internal Medicine, University Hospital Cologne, Excellence Center for Medical Mycology (ECMM), Cologne, Germany.
³⁶ Faculty of Medicine and University Hospital Cologne, Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany.
³⁷ Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD) and Excellence Center for Medical Mycology (ECMM), and.
³⁸ Faculty of Medicine and University Hospital Cologne, Clinical Trials Centre Cologne (ZKS Köln), University of Cologne, Cologne, Germany.
³⁹ German Centre for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany.
⁴⁰ Faculty of Medicine, University of Cologne, and Translational Research, University Hospital Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany; Faculty of Medicine, University of Cologne, and Clinical Trials Centre Cologne (ZKS Köln), University Hospital Cologne, Cologne, Germany, Faculty of Medicine, University of Cologne, and University Hospital Cologne, Center for Molecular Medicine Cologne (CMMC), Cologne, Germany, German Centre for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany.
⁴¹ Service d'Hématologie Oncologie, Centre Hospitalier de Versailles, Le Chesnay, France, Université Paris-Saclay, UVSQ, INSERM, Équipe Exposome et Hérédité, CESP, Villejuif, France; and.
⁴² Hematology Unit, Fondazione Policlinico Universitario Agostino Gemelli-IRCCS, Rome, Italy, Hematology Unit, Università Cattolica del Sacro Cuore, Rome, Italy.

PMID: 35500220
PMCID: PMC9068260
DOI: 10.1182/bloodadvances.2022007357

COVID-19 and hairy-cell leukemia: an EPICOVIDEHA survey

Sylvain Lamure et al. Blood Adv. 2022.

. 2022 Jul 12;6(13):3870-3874.

doi: 10.1182/bloodadvances.2022007357.

Authors

Affiliations

¹ Department of Clinical Hematology, Montpellier University Hospital, IGMM UMR5535 Centre National de la Recherche Scientifique (CNRS), University of Montpellier, Montpellier, France.
² Faculty of Medicine and University Hospital Cologne, Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
³ Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD) and Excellence Center for Medical Mycology (ECMM), University of Cologne, Cologne, Germany.
⁴ Service d'Hématologie Oncologie, Centre Hospitalier de Versailles, Le Chesnay, France.
⁵ University Hospital Dubrava, Zagreb, Croatia.
⁶ Hematology and Stem Cell Transplant Unit, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Regina Elena National Cancer Institute, Rome, Italy.
⁷ Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
⁸ Oncology Center, Mansoura University, Mansoura, Egypt.
⁹ Division of Hematology, Dokuz Eylul University, Izmir, Turkey.
¹⁰ University Hospital Centre Rijeka, and Croatian Cooperative Group for Hematological Diseases (CROHEM), Faculty of Medicine and Faculty of Health Studies University of Rijeka, Rijeka, Croatia.
¹¹ Hospital Universitario Marqués de Valdecilla, Santander, Spain.
¹² Department of Hematology, Ospedale San Bortolo, Vicenza, Italy.
¹³ University Clinic of Hematology, Skopje, Republic of North Macedonia.
¹⁴ Department of Hematology, Ankara University School of Medicine, Ankara, Turkey.
¹⁵ Hematology and Bone Marrow Unit, University of Parma Hospital, Parma, Italy.
¹⁶ Azienda Sanitaria Universitaria del Friuli Centrale, Udine, Italy.
¹⁷ Fundacion Jimenez Diaz University Hospital, Health Research Institute IIS-FJD, Madrid, Spain.
¹⁸ Institut de Cancérologie de Strasbourg Europe, Strasbourg, France.
¹⁹ King's College Hospital, London, United Kingdom.
²⁰ Department of Hematology, Hospital Universitario de Burgos, Burgos, Spain.
²¹ Departamento de Hematologia, Instituto Português de Oncologia, Lisboa, Portugal.
²² Hospital Universitario Puerta de Hierro, Majadahonda, Spain.
²³ Hematology Unit, ASST-Spedali Civili, Brescia, Italy.
²⁴ Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden.
²⁵ Department of Internal Medicine, Adrz, Goes, The Netherlands.
²⁶ Centro Hospitalar e Universitário São João, Porto, Portugal.
²⁷ School of Medicine, University of Zagreb, and Croatian Cooperative Group for Hematological Diseases (CROHEM), Zagreb, Croatia.
²⁸ Health Research Institute IIS-FJD, Fundacion Jimenez Diaz University Hospital, Madrid, Spain.
²⁹ Stem Cell Transplant Center, AOU Citta' della Salute e della Scienza, Turin, Italy.
³⁰ University of Milan and Fondazione IRCCS, Istituto Nazionale dei Tumori, Milan, Italy.
³¹ Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, San Diego, and Clinical and Translational Fungal Research-Working Group, University of California San Diego, La Jolla, CA, and Division of Infectious Diseases, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
³² North-Western State Medical University named after Iliá Ilich Méchnikov, Saint-Petersburg, Russia.
³³ Department of Hematological Medicine, Kings College Hospital NHS Foundation Trust, London, United Kingdom.
³⁴ Department of Medicine and Surgery, University of Insubria and ASST Sette Laghi, Ospedale di Circolo of Varese, Varese, Italy.
³⁵ Service d'Hématologie Clinique et de Thérapie Cellulaire, Hôpital Saint Antoine, Assistance Publique-Hôpitaux de Paris, Sorbonne University, INSERM UMRS 938, Paris, France, Faculty of Medicine, University of Cologne, and Department I of Internal Medicine, University Hospital Cologne, Excellence Center for Medical Mycology (ECMM), Cologne, Germany.
³⁶ Faculty of Medicine and University Hospital Cologne, Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany.
³⁷ Department I of Internal Medicine, Faculty of Medicine and University Hospital Cologne, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD) and Excellence Center for Medical Mycology (ECMM), and.
³⁸ Faculty of Medicine and University Hospital Cologne, Clinical Trials Centre Cologne (ZKS Köln), University of Cologne, Cologne, Germany.
³⁹ German Centre for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany.
⁴⁰ Faculty of Medicine, University of Cologne, and Translational Research, University Hospital Cologne, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany; Faculty of Medicine, University of Cologne, and Clinical Trials Centre Cologne (ZKS Köln), University Hospital Cologne, Cologne, Germany, Faculty of Medicine, University of Cologne, and University Hospital Cologne, Center for Molecular Medicine Cologne (CMMC), Cologne, Germany, German Centre for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany.
⁴¹ Service d'Hématologie Oncologie, Centre Hospitalier de Versailles, Le Chesnay, France, Université Paris-Saclay, UVSQ, INSERM, Équipe Exposome et Hérédité, CESP, Villejuif, France; and.
⁴² Hematology Unit, Fondazione Policlinico Universitario Agostino Gemelli-IRCCS, Rome, Italy, Hematology Unit, Università Cattolica del Sacro Cuore, Rome, Italy.

PMID: 35500220
PMCID: PMC9068260
DOI: 10.1182/bloodadvances.2022007357

No abstract available

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Figures

**Figure 1.**
**Overall survival of patients with COVID-19 and HCL.** Probability of overall survival of 39 patients with hairy cell leukemia after COVID-19 diagnosis (A) and comparison of the survival of 17 patients who had a previous treatment with cladribine with 19 patients who received no treatment (B). Kaplan-Meier survival analysis made with Prism 9 version 9.3.1 (GraphPad 2021).

See this image and copyright information in PMC

References

1. Kreitman RJ. Hairy cell leukemia: present and future directions. Leuk Lymphoma. 2019;60(12):2869-2879. - PMC - PubMed
1. Swerdlow SH, Campo E, Harris NL, et al. . WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues, vol. 2. Lyon, France: IARC; 2008.
1. Bouza E, Burgaleta C, Golde DW. Infections in hairy-cell leukemia. Blood. 1978;51(5):851-859. - PubMed
1. Kraut E. Infectious complications in hairy cell leukemia. Leuk Lymphoma. 2011;52(suppl 2):50-52. - PubMed
1. Grever MR, Abdel-Wahab O, Andritsos LA, et al. . Consensus guidelines for the diagnosis and management of patients with classic hairy cell leukemia. Blood. 2017;129(5):553-560. - PMC - PubMed

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COVID-19 and hairy-cell leukemia: an EPICOVIDEHA survey

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COVID-19 and hairy-cell leukemia: an EPICOVIDEHA survey

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