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. 2022 Apr;19(4):247-258.
doi: 10.30773/pi.2021.0277. Epub 2022 Apr 22.

Real-World Evidence for the Association Between Pneumonia-Related Intensive Care Unit Stay and Dementia

Chun-Han Wu  1 , Chung-Kan Peng  1 , Chi-Hsian Chung  2   3   4 , Wu-Chien Chien  2   3   4   5 , Nian-Sheng Tzeng  6   7
Affiliations

Real-World Evidence for the Association Between Pneumonia-Related Intensive Care Unit Stay and Dementia

Chun-Han Wu et al. Psychiatry Investig. 2022 Apr.

Abstract

Objective: There is limited clarity concerning the risk of dementia after pneumonia with intensive care unit (ICU) stay. We conducted a nationwide cohort study, which aimed to investigate the impact of dementia after pneumonia with and without intensive care unit admission.

Methods: Data was obtained from Taiwan's National Health Insurance Research Database between 2000 and 2015. A total of 7,473 patients were identified as having pneumonia required ICU stay, along with 22,419 controls matched by sex and age. After adjusting for confounding factors, multivariate Cox regression model analysis was used to compare the risk of developing dementia during the 15-years follow-up period.

Results: The enrolled pneumonia patients with ICU admission had a dementia rate of 9.89%. Pneumonia patients without ICU admission had a dementia rate of 9.21%. The multivariate Cox regression model analysis revealed that the patients with ICU stay had the higher risk of dementia, with a crude hazard ratio of 3.371 (95% confidence interval, 3.093-3.675; p<0.001).

Conclusion: This study indicated that pneumonia with ICU stay is associated with an increased risk of dementia. A 3-fold risk of dementia was observed in patients admitted to the ICU compared to the control group.

Keywords: Dementia; Intensive care; Pneumonia.

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Conflict of interest statement

Conflicts of Interest

The authors have no potential conflicts of interest to disclose.

Figures

Figure 1.
Figure 1.
A: The flowchart of study sample selection. B: Kaplan–Meier for cumulative incidence of dementia among pneumonia patients aged 50 and over stratified by intensive care unit (ICU) with log-rank test.
See this image and copyright information in PMC

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