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Comment
. 2022 Jul;38(7):498-500.
doi: 10.1016/j.pt.2022.04.001. Epub 2022 Apr 29.

Shared sugars - parasite glycan homology in HIV-1 vaccine design

Lachlan P Deimel  1 , Quentin J Sattentau  2
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Comment

Shared sugars - parasite glycan homology in HIV-1 vaccine design

Lachlan P Deimel et al. Trends Parasitol. 2022 Jul.

Abstract

Immune tolerance to self-glycans is a host mechanism to avoid autoimmunity, which is exploited by HIV-1 coating its envelope glycoproteins with glycans to evade neutralising antibodies (nAbs). Huettner et al. describe cross-reactivity between Schistosoma mansoni glycans and HIV-1 envelope glycoprotein glycans, suggesting a strategy for induction of HIV-1 nAbs by vaccination.

Keywords: HIV-1; antibody; glycan; helminth; parasite.

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