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Review
. 2022 Sep;30(9):1-12.
doi: 10.1007/s00520-022-07013-6. Epub 2022 Apr 30.

Effects of physical exercise on body fat and laboratory biomarkers in cancer patients: a meta-analysis of 35 randomized controlled trials

Chang Hu  1   2 , Jialing Tang  3 , Yang Gao  4 , Ran Cao  5
Affiliations
Review

Effects of physical exercise on body fat and laboratory biomarkers in cancer patients: a meta-analysis of 35 randomized controlled trials

Chang Hu et al. Support Care Cancer. 2022 Sep.

Abstract

Background: A growing number of articles had reported the beneficial effects of physical exercise on reduced risks of cancer recurrence and mortality. However, the associations between physical exercise and laboratory biomarkers still had controversy. As we knew, this meta-analysis of randomized controlled trials (RCTs) was the first time for us to comprehensively clarify their relationships in cancer patients.

Methods: We comprehensively searched the PubMed, Cochrane Central, EMBASE, Web of Science, and SportDiscus online databases to identify eligible articles, up to June 1, 2021. Pooled standardized mean differences (SMDs) with 95% confidence intervals (CIs) were utilized to clarify their associations. Sensitivity analysis was performed to assess the impact of the individual on overall and Begg's/Egger's plot was utilized to evaluate potential publication bias.

Results: Finally, 35 randomized controlled trials (RCTs) were finally enrolled in this meta-analysis. Our results indicated that physical exercise could significantly reduce BMI (pooled SMD = -0.32 - 0.56 to -0.09)), body weight (pooled SMD = -0.31 (-0.54 to -0.08)), body fat (pooled SMD = -0.44 (-0.70 to -0.18)), waist circumference (pooled SMD = -0.50 (-0.76 to -0.23)), hip circumference (pooled SMD = -0.54 (-0.80 to -0.28)), triglyceride (pooled SMD = -0.35 (-0.69 to -0.02)), fasting insulin (pooled SMD = -0.38 (-0.54 to -0.22)), glucose (pooled SMD = -0.56 (-0.84 to -0.28)), insulin resistance (pooled SMD = -0.40 (-0.72 to -0.07)), CRP (pooled SMD = -0.97 (-1.48 to -0.46)), IGF-1 levels (pooled SMD = -0.56 (-0.83 to -0.29)) and remarkably increase IGFBP-3 levels (pooled SMD = 0.81 (0.45 to 1.17)). Further sensitivity analysis and Begg's or Egger's test suggested that our results were robust with no significant publication bias.

Conclusions: Our results shed light on the beneficial effects of physical exercise on cancer patients by means of BMI/weight change and various biomarkers alteration (insulin-glucose pathways or inflammatory biomarkers). Our results were anticipated for clinical application to improve cancer patients' prognosis.

Keywords: Biomarkers; Body fat; Cancer; Meta-analysis; Physical exercise; Randomized controlled trials.

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References

    1. Siegel RL et al (2021) Cancer Statistics, 2021. CA Cancer J Clin 71(1):7–33 - PubMed - DOI
    1. Haque R et al (2014) Comorbidities and cardiovascular disease risk in older breast cancer survivors. Am J Manag Care 20(1):86–92 - PubMed - PMC
    1. Miller R, Northey J, Toohey K (2020) Physical exercise and cancer: exploring chemotherapy infusion as an opportunity for movement. Semin Oncol Nurs 36(5):151068 - PubMed - DOI
    1. Spence RR et al (2020) Physical activity and exercise guidelines for people with cancer: why are they needed, who should use them, and when? Semin Oncol Nurs 36(5):151075 - PubMed - DOI
    1. Kang DW et al (2017) Effects of exercise on insulin, IGF axis, adipocytokines, and inflammatory markers in breast cancer survivors: a systematic review and meta-analysis. Cancer Epidemiol Biomarkers Prev 26(3):355–365 - PubMed - DOI