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Review
. 2022 Jun;73(2):137-148.
doi: 10.1007/s42977-022-00117-4. Epub 2022 May 2.

The role of K63-linked polyubiquitin in several types of autophagy

Anna Dósa  1 , Tamás Csizmadia  2
Affiliations
Review

The role of K63-linked polyubiquitin in several types of autophagy

Anna Dósa et al. Biol Futur. 2022 Jun.

Abstract

Lysosomal-dependent self-degradative (autophagic) mechanisms are essential for the maintenance of normal homeostasis in all eukaryotic cells. Several types of such self-degradative and recycling pathways have been identified, based on how the cellular self material can incorporate into the lysosomal lumen. Ubiquitination, a well-known and frequently occurred posttranslational modification has essential role in all cell biological processes, thus in autophagy too. The second most common type of polyubiquitin chain is the K63-linked polyubiquitin, which strongly connects to some self-degradative mechanisms in the cells. In this review, we discuss the role of this type of polyubiquitin pattern in numerous autophagic processes.

Keywords: Lysine 63 linkage specific ubiquitin; Lysosome; Vesicular trafficking.

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