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. 2022 Apr;172(6):709-712.
doi: 10.1007/s10517-022-05461-y. Epub 2022 May 2.

Effects of a New Antithrombotic Drug GRS, a Soluble Guanylate Cyclase Stimulator, on Endothelial Dysfunction in Rats with Myocardial Infarction

V V Bykov  1   2 , V I Smol'yakova  3 , G A Chernysheva  3 , O I Aliev  3 , A M Anishchenko  4   3 , A V Sidekhmenova  3 , O I Dunaeva  3 , S A Stankevich  5 , V A Khazanov  5
Affiliations

Effects of a New Antithrombotic Drug GRS, a Soluble Guanylate Cyclase Stimulator, on Endothelial Dysfunction in Rats with Myocardial Infarction

V V Bykov et al. Bull Exp Biol Med. 2022 Apr.

Abstract

New antithrombotic drug GRS, a soluble guanylate cyclase stimulator, after repeated administration in a dose of 10 mg/kg alleviates the symptoms of endothelial dysfunction in rats with myocardial infarction; it restores antiplatelet activity of the blood vessel wall and vasodilatory function of the endothelium without producing significant effect on endothelium-independent vasodilation. GRS also has direct antiaggregant and antihypertensive effects in therapeutic doses. The obtained data suggest that GRS can be therapeutically useful in patients with cardiovascular diseases accompanied by endothelial dysfunction.

Keywords: endothelial dysfunction; myocardial infarction; soluble guanylate cyclase stimulator GRS.

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