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Clinical Trial
. 2022 Aug;109(2):162-165.
doi: 10.1111/ejh.13784. Epub 2022 May 11.

Polatuzumab vedotin plus bendamustine and rituximab in patients with relapsed/refractory diffuse large B-cell lymphoma in the real world

Prokop Vodicka  1 , Katerina Benesova  1 , Andrea Janikova  2 , Vit Prochazka  3 , David Belada  4 , Heidi Mocikova  5 , Katerina Steinerova  6 , Juraj Duras  7 , Josef Karban  1 , Veronika Hanackova  3 , Alice Sykorova  4 , Ales Obr  3 , Marek Trneny  1
Affiliations
Clinical Trial

Polatuzumab vedotin plus bendamustine and rituximab in patients with relapsed/refractory diffuse large B-cell lymphoma in the real world

Prokop Vodicka et al. Eur J Haematol. 2022 Aug.

Abstract

Objectives: Polatuzumab vedotin with bendamustine and rituximab (Pola-BR) was approved for treatment of transplant-ineligible patients with relapsed/refractory DLBCL (R/R DLBCL). However, the number of patients treated in the GO29365 trial including the extension cohort was limited, and more data evaluating the efficacy of this treatment regimen is needed.

Methods: We analyzed 21 patients with R/R DLBCL to determine real-life efficacy and safety of Pola-BR regimen. Data of all patients entered the database of the NiHiL project (NCT03199066).

Results: Median overall survival was 8.7 months, and progression-free survival 3.8 months. The overall response rate was 33%. Grade 3-4 neutropenia was detected in 29%, thrombocytopenia in 38%, anemia in 19%, infections in 24% cases, and peripheral neuropathy in 5%. Discontinuation of treatment was caused by progression in 50%, adverse events in 31%, and intended bridging to CAR-T therapy in 19%.

Conclusion: Although the outcome of patients is worse than in GO29365 trial, the use of Pola-BR regimen in the real world demonstrates tolerable toxicity profile and efficacy in transplant-ineligible patients with R/R DLBCL. Moreover, this regimen might represent a perspective option as a bridge to CAR-T therapy.

Keywords: DLBCL; polatuzumab vedotin; real world.

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References

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