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. 2022:1372:1-14.
doi: 10.1007/978-981-19-0394-6_1.

Sphingolipids and Cholesterol

Xian-Cheng Jiang  1 , Zhiqiang Li  2
Affiliations

Sphingolipids and Cholesterol

Xian-Cheng Jiang et al. Adv Exp Med Biol. 2022.

Abstract

Sphingolipids and cholesterol are two lipid partners on cellular membranes where they form specific microdomains, named lipid rafts, which mediate specific cell functions. Sphingomyelin (SM) is one of the major sphingolipids. SM and free cholesterol are also two key lipids on the monolayer of plasma lipoproteins, including chylomicron, very low-density lipoprotein (VLDL), low-density lipoprotein (LDL), and high-density lipoprotein (HDL), which participate in lipid transport in the circulation. Thus, sphingolipids and cholesterol play a fundamental role in cell membrane structure and blood lipid transport. In this chapter we will discuss the relationship between both lipids, on the cell membrane and in the circulation, as well as the impact of such relationship in the development of metabolic diseases.

Keywords: Cell membrane lipids; Cholesterol; Lipids in the circulation; Sphingolipids; Sphingomyelin.

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References

    1. Merrill AH Jr. (1983) Characterization of serine palmitoyltransferase activity in Chinese hamster ovary cells. Biochim Biophys Acta 754, 284–291 - PubMed
    1. Hojjati MR, Li Z, and Jiang XC (2005) Serine palmitoyl-CoA transferase (SPT) deficiency and sphingolipid levels in mice. Biochim Biophys Acta 1737, 44–51 - PubMed
    1. Gatt S, and Bierman EL (1980) Sphingomyelin suppresses the binding and utilization of low density lipoproteins by skin fibroblasts. J Biol Chem 255, 3371–3376 - PubMed
    1. Slotte JP, and Bierman EL (1988) Depletion of plasma-membrane sphingomyelin rapidly alters the distribution of cholesterol between plasma membranes and intracellular cholesterol pools in cultured fibroblasts. Biochem J 250, 653–658 - PMC - PubMed
    1. Slotte JP (1999) Sphingomyelin-cholesterol interactions in biological and model membranes. Chem Phys Lipids 102, 13–27 - PubMed