Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2022 May 4;60(8):e187-e189.
doi: 10.1515/cclm-2022-0361. Print 2022 Jul 26.

Fragments of alpha-1-antitrypsin in patients with severe COVID-19 and bacterial pulmonary sepsis

Arite Bigalke  1 , Charles Neu  2   3 , Ricardo Esper Treml  2   3 , Sina M Coldewey  2   3 , Michael Kiehntopf  1
Affiliations
Comment

Fragments of alpha-1-antitrypsin in patients with severe COVID-19 and bacterial pulmonary sepsis

Arite Bigalke et al. Clin Chem Lab Med. .
No abstract available

Keywords: COVID; alpha-1-antitrypsin; inflammation; proteases.

PubMed Disclaimer

Comment on

  • Protease-antiprotease imbalance in patients with severe COVID-19.
    Zerimech F, Jourdain M, Onraed B, Bouchecareilh M, Sendid B, Duhamel A, Balduyck M, Pigny P; LICORNE Study Groupa. Zerimech F, et al. Clin Chem Lab Med. 2021 Mar 8;59(8):e330-e334. doi: 10.1515/cclm-2021-0137. Print 2021 Jul 27. Clin Chem Lab Med. 2021. PMID: 33675194 No abstract available.

References

    1. Zerimech, F, Jourdain, M, Onraed, B, Bouchecareilh, M, Sendid, B, Duhamel, A, et al.. Protease-antiprotease imbalance in patients with severe COVID-19. Clin Chem Lab Med 2021;59:e330–4. https://doi.org/10.1515/cclm-2021-0137.
    1. Vianello, A, Braccioni, F. Geographical overlap between alpha-1 antitrypsin deficiency and COVID-19 infection in Italy: casual or causal? Arch Bronconeumol 2020;56:609–10. https://doi.org/10.1016/j.arbres.2020.05.015.
    1. Ritzmann, F, Chitirala, P, Krüger, N, Hoffmann, M, Zuo, W, Lammert, F, et al.. Therapeutic application of alpha-1 antitrypsin in COVID-19. Am J Respir Crit Care Med 2021;204:224–7. https://doi.org/10.1164/rccm.202104-0833LE.
    1. McElvaney, OJ, McEvoy, NL, McElvaney, OF, Carroll, TP, Murphy, MP, Dunlea, DM, et al.. Characterization of the inflammatory response to severe COVID-19 illness. Am J Respir Crit Care Med 2020;202:812–21. https://doi.org/10.1164/rccm.202005-1583oc.
    1. McKelvey, MC, Brown, R, Ryan, S, Mall, MA, Weldon, S, Taggart, CC. Proteases, mucus, and mucosal immunity in chronic lung disease. Int J Mol Sci 2021;22:5018. https://doi.org/10.3390/ijms22095018.

Substances