International League Against Epilepsy classification and definition of epilepsy syndromes with onset at a variable age: position statement by the ILAE Task Force on Nosology and Definitions

Kate Riney^{1

2}, Alicia Bogacz³, Ernest Somerville^{4

5}, Edouard Hirsch^{6

7

8}, Rima Nabbout^{9

10

11}, Ingrid E Scheffer¹², Sameer M Zuberi^{11

13

14}, Taoufik Alsaadi¹⁵, Satish Jain¹⁶, Jacqueline French¹⁷, Nicola Specchio¹⁸, Eugen Trinka^{19

20

21}, Samuel Wiebe²², Stéphane Auvin^{23

24

25}, Leonor Cabral-Lim²⁶, Ansuya Naidoo^{27

28}, Emilio Perucca^{29

30}, Solomon L Moshé^{31

32}, Elaine C Wirrell³³, Paolo Tinuper^{34

35}

Affiliations

¹ Neurosciences Unit, Queensland Children's Hospital, South Brisbane, Queensland, Australia.
² Faculty of Medicine, University of Queensland, South Brisbane, Queensland, Australia.
³ Institute of Neurology, University of the Republic, Montevideo, Uruguay.
⁴ Prince of Wales Hospital, Sydney, New South Wales, Australia.
⁵ University of New South Wales, Sydney, New South Wales, Australia.
⁶ Francis Rohmer Epilepsy Unit, Hautepierre Hospital, Strasbourg, France.
⁷ National Institute of Health and Medical Research 1258, Strasbourg, France.
⁸ Federation of Translational Medicine of Strasbourg, University of Strasbourg, Strasbourg, France.
⁹ Reference Centre for Rare Epilepsies, Assistance Publique - Hôpitaux de Paris, Department of Pediatric Neurology, Necker-Enfants Malades Hospital, Member of Epicare, Paris, France.
¹⁰ Imagine Institute, National Institute of Health and Medical Research Mixed Unit of Research 1163, Paris, France.
¹¹ University City University, Paris, France.
¹² Austin Health, Royal Children's Hospital, Florey Institute and Murdoch Children's Research Institute, University of Melbourne, Melbourne, Victoria, Australia.
¹³ Paediatric Neurosciences Research Group, Royal Hospital for Children, Glasgow, UK.
¹⁴ Institute of Health & Wellbeing, University of Glasgow, Glasgow, UK.
¹⁵ Department of Neurology, American Center for Psychiatry and Neurology, Abu Dhabi, United Arab Emirates.
¹⁶ Indian Epilepsy Center, New Delhi, India.
¹⁷ New York University Grossman School of Medicine and NYU Langone Health, New York, New York, USA.
¹⁸ Rare and Complex Epilepsy Unit, Department of Neuroscience, Bambino Gesù Children's Hospital, Scientific Institute for Research and Health Care, member of EpiCARE, Rome, Italy.
¹⁹ Department of Neurology, Christian Doppler University Hospital, Paracelsus Medical University, Center for Cognitive Neuroscience, member of EpiCARE, Salzburg, Austria.
²⁰ Neuroscience Institute, Christian Doppler University Hospital, Center for Cognitive Neuroscience, Salzburg, Austria.
²¹ Department of Public Health, Health Services Research and Health Technology Assessment, University for Health Sciences, Medical Informatics, and Technology, Hall in Tirol, Austria.
²² Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada.
²³ Institut Universitaire de France, Paris, France.
²⁴ Paediatric Neurology, Assistance Publique - Hôpitaux de Paris, Robert-Debré Hospital, Paris, France.
²⁵ University of Paris, Paris, France.
²⁶ Department of Neurosciences, College of Medicine and Philippine General Hospital, Health Sciences Center, University of the Philippines Manila, Manila, the Philippines.
²⁷ Neurology Unit, Greys Hospital, Pietermaritzburg, South Africa.
²⁸ Department of Neurology, University of KwaZulu Natal, KwaZulu Natal, South Africa.
²⁹ Department of Medicine, Austin Health, University of Melbourne, Heidelberg, Victoria, Australia.
³⁰ Department of Neuroscience, Monash University, Melbourne, Victoria, Australia.
³¹ Isabelle Rapin Division of Child Neurology, Saul R. Korey Department of Neurology and Departments of Neuroscience and Pediatrics, Albert Einstein College of Medicine, New York, New York, USA.
³² Montefiore Medical Center, Bronx, New York, USA.
³³ Divisions of Child and Adolescent Neurology and Epilepsy, Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
³⁴ Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
³⁵ Reference Centre for Rare and Complex Epilepsies, IRCCS Istituto delle Scienze Neurologiche, Bologna, Italy.

PMID: 35503725
DOI: 10.1111/epi.17240

Free article

International League Against Epilepsy classification and definition of epilepsy syndromes with onset at a variable age: position statement by the ILAE Task Force on Nosology and Definitions

Kate Riney et al. Epilepsia. 2022 Jun.

Free article

. 2022 Jun;63(6):1443-1474.

doi: 10.1111/epi.17240. Epub 2022 May 3.

Authors

Affiliations

¹ Neurosciences Unit, Queensland Children's Hospital, South Brisbane, Queensland, Australia.
² Faculty of Medicine, University of Queensland, South Brisbane, Queensland, Australia.
³ Institute of Neurology, University of the Republic, Montevideo, Uruguay.
⁴ Prince of Wales Hospital, Sydney, New South Wales, Australia.
⁵ University of New South Wales, Sydney, New South Wales, Australia.
⁶ Francis Rohmer Epilepsy Unit, Hautepierre Hospital, Strasbourg, France.
⁷ National Institute of Health and Medical Research 1258, Strasbourg, France.
⁸ Federation of Translational Medicine of Strasbourg, University of Strasbourg, Strasbourg, France.
⁹ Reference Centre for Rare Epilepsies, Assistance Publique - Hôpitaux de Paris, Department of Pediatric Neurology, Necker-Enfants Malades Hospital, Member of Epicare, Paris, France.
¹⁰ Imagine Institute, National Institute of Health and Medical Research Mixed Unit of Research 1163, Paris, France.
¹¹ University City University, Paris, France.
¹² Austin Health, Royal Children's Hospital, Florey Institute and Murdoch Children's Research Institute, University of Melbourne, Melbourne, Victoria, Australia.
¹³ Paediatric Neurosciences Research Group, Royal Hospital for Children, Glasgow, UK.
¹⁴ Institute of Health & Wellbeing, University of Glasgow, Glasgow, UK.
¹⁵ Department of Neurology, American Center for Psychiatry and Neurology, Abu Dhabi, United Arab Emirates.
¹⁶ Indian Epilepsy Center, New Delhi, India.
¹⁷ New York University Grossman School of Medicine and NYU Langone Health, New York, New York, USA.
¹⁸ Rare and Complex Epilepsy Unit, Department of Neuroscience, Bambino Gesù Children's Hospital, Scientific Institute for Research and Health Care, member of EpiCARE, Rome, Italy.
¹⁹ Department of Neurology, Christian Doppler University Hospital, Paracelsus Medical University, Center for Cognitive Neuroscience, member of EpiCARE, Salzburg, Austria.
²⁰ Neuroscience Institute, Christian Doppler University Hospital, Center for Cognitive Neuroscience, Salzburg, Austria.
²¹ Department of Public Health, Health Services Research and Health Technology Assessment, University for Health Sciences, Medical Informatics, and Technology, Hall in Tirol, Austria.
²² Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada.
²³ Institut Universitaire de France, Paris, France.
²⁴ Paediatric Neurology, Assistance Publique - Hôpitaux de Paris, Robert-Debré Hospital, Paris, France.
²⁵ University of Paris, Paris, France.
²⁶ Department of Neurosciences, College of Medicine and Philippine General Hospital, Health Sciences Center, University of the Philippines Manila, Manila, the Philippines.
²⁷ Neurology Unit, Greys Hospital, Pietermaritzburg, South Africa.
²⁸ Department of Neurology, University of KwaZulu Natal, KwaZulu Natal, South Africa.
²⁹ Department of Medicine, Austin Health, University of Melbourne, Heidelberg, Victoria, Australia.
³⁰ Department of Neuroscience, Monash University, Melbourne, Victoria, Australia.
³¹ Isabelle Rapin Division of Child Neurology, Saul R. Korey Department of Neurology and Departments of Neuroscience and Pediatrics, Albert Einstein College of Medicine, New York, New York, USA.
³² Montefiore Medical Center, Bronx, New York, USA.
³³ Divisions of Child and Adolescent Neurology and Epilepsy, Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
³⁴ Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
³⁵ Reference Centre for Rare and Complex Epilepsies, IRCCS Istituto delle Scienze Neurologiche, Bologna, Italy.

PMID: 35503725
DOI: 10.1111/epi.17240

Abstract

The goal of this paper is to provide updated diagnostic criteria for the epilepsy syndromes that have a variable age of onset, based on expert consensus of the International League Against Epilepsy Nosology and Definitions Taskforce (2017-2021). We use language consistent with current accepted epilepsy and seizure classifications and incorporate knowledge from advances in genetics, electroencephalography, and imaging. Our aim in delineating the epilepsy syndromes that present at a variable age is to aid diagnosis and to guide investigations for etiology and treatments for these patients.

Keywords: Rasmussen syndrome; epilepsy with reading-induced seizures; focal epilepsy syndromes; mesial temporal lobe epilepsy with hippocampal sclerosis; progressive myoclonus epilepsies.

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References

REFERENCES

1. Wirrell EC, Nabbout R, Scheffer IE, Alsaadi T, Bogacz A, French J, et al. Methodology for classification and definition of epilepsy syndromes with list of syndromes: report of the ILAE Task Force on Nosology and Definitions. Epilepsia. In press.
1. Zuberi SM, Wirrell E, Yozawitz E, Wilmshurst J, Specchio N, Riney K, et al. ILAE classification and definition of epilepsy syndromes in the neonate and infant: position statement by the ILAE Task Force on Nosology and Definitions. Epilepsia. In press.
1. Specchio N, Wirrell EC, Scheffer IE, Nabbout R, Riney K, Samia P, et al. ILAE classification and definition of epilepsy syndromes with onset in childhood: position statement by the ILAE Task Force on Nosology and Definitions. Epilepsia. In press.
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1. Richards S, Aziz N, Bale S, Bick D, Das S, Gastier-Foster J, et al. Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology. Genet Med. 2015;17(5):405-24. https://doi.org/https://doi.org/10.1038/gim.2015.30

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International League Against Epilepsy classification and definition of epilepsy syndromes with onset at a variable age: position statement by the ILAE Task Force on Nosology and Definitions

Affiliations

International League Against Epilepsy classification and definition of epilepsy syndromes with onset at a variable age: position statement by the ILAE Task Force on Nosology and Definitions

Authors

Affiliations

Abstract

References

REFERENCES

MeSH terms

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical