Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2022 Apr 15;376(6590):eabn7270.
doi: 10.1126/science.abn7270. Epub 2022 Apr 15.

Response to Comment on "Impact of neurodegenerative diseases on human adult hippocampal neurogenesis"

J Terreros-Roncal #  1   2   3 , E P Moreno-Jiménez #  1   2   3 , M Flor-García #  1   2   3 , C B Rodríguez-Moreno  1   3 , M F Trinchero  4 , B Márquez-Valadez  1   3 , F Cafini  5 , A Rábano  6 , M Llorens-Martín  1   3
Affiliations
Comment

Response to Comment on "Impact of neurodegenerative diseases on human adult hippocampal neurogenesis"

J Terreros-Roncal et al. Science. .

Abstract

Rakic and colleagues challenge the use of extensively validated adult hippocampal neurogenesis (AHN) markers and postulate an alternative interpretation of some of the data included in our study. In Terreros-Roncal et al., reconstruction of the main stages encompassed by human AHN revealed enhanced vulnerability of this phenomenon to neurodegenerative diseases. Here, we clarify points and ambiguities raised by these authors.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Vimentin staining in the human DG (A). Relative cell density in the SGZ (B). ML: Molecular layer. GCL: Granule cell layer. SGZ: Subgranular zone. Scale bar: 10 μm. *** p < 0.001.
See this image and copyright information in PMC

Comment on

References

    1. Arellano J, D A, Rakic P. Comment on Impact of neurodegenerative diseases on human adult hippocampal neurogenesis. Science. 2022 published online Epub 2022, X, X XXX. - PubMed
    1. Terreros-Roncal J, Moreno-Jimenez EP, Flor-Garcia M, Rodriguez-Moreno CB, Trinchero MF, Cafini F, Rabano A, Llorens-Martin M. Impact of neurodegenerative diseases on human adult hippocampal neurogenesis. Science. 2021;374:1106–1113. doi: 10.1126/science.abl5163. published online Epub Nov 26. - DOI - PMC - PubMed
    1. Martin-Suarez S, Valero J, Muro-Garcia T, Encinas JM. Phenotypical and functional heterogeneity of neural stem cells in the aged hippocampus. Aging cell. 2019;18:e12958. doi: 10.1111/acel.12958. published online Epub Aug. - DOI - PMC - PubMed
    1. Coras R, Siebzehnrubl FA, Pauli E, Huttner HB, Njunting M, Kobow K, Villmann C, Hahnen E, Neuhuber W, Weigel D, Buchfelder M, et al. Low proliferation and differentiation capacities of adult hippocampal stem cells correlate with memory dysfunction in humans. Brain : a journal of neurology. 2010;133:3359–3372. doi: 10.1093/brain/awq215. published online Epub Nov. - DOI - PubMed
    1. Moreno-Jimenez EP, Flor-Garcia M, Terreros-Roncal J, Rabano A, Cafini F, Pallas-Bazarra N, Avila J, Llorens-Martin M. Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer’s disease. Nat Med. 2019;25:554–560. doi: 10.1038/s41591-019-0375-9. published online Epub Apr. - DOI - PubMed