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Review
. 2023:61:35-48.
doi: 10.1007/7854_2022_362.

Infections, Inflammation, and Psychiatric Illness: Review of Postmortem Evidence

Maree J Webster  1
Affiliations
Review

Infections, Inflammation, and Psychiatric Illness: Review of Postmortem Evidence

Maree J Webster. Curr Top Behav Neurosci. 2023.

Abstract

While there is an abundance of epidemiological evidence implicating infectious agents in the etiology of severe mental illnesses, postmortem studies have not yet detected an increased incidence of microbial nucleic acid or proteins in the brains of people with mental illness. Nevertheless, abnormally expressed immune and inflammatory markers have consistently been found in the postmortem brain of patients with schizophrenia and mood disorders. Some of these abnormalities may be the result of an infection in utero or early in life that not only impacted the developing immune system but also the developing neurons of the brain. Some of the immune markers that are consistently found to be upregulated in schizophrenia implicate a possible viral infection and the blood brain barrier in the etiology and neuropathology of the disorder.

Keywords: Bipolar disorder; Brain; Major depressive disorder; Schizophrenia.

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References

    1. Arias I, Sorlozano A, Villegas E, de Dios Luna J, McKenney K, Cervilla J, Gutierrez B, Gutierrez J (2012) Infectious agents associated with schizophrenia: a meta-analysis. Schiz Res 136(1):128–136 - DOI
    1. Bergon A, Belzeaux R, Comte M, Pelletier F, Hervé M, Gardiner EJ, Beveridge NJ, Liu B, Carr V, Scott RJ, Kelly B, Cairns MJ, Kumarasinghe N, Schall U, Blin O, Boucraut J, Tooney PA, Fakra E, Ibrahim E (2015) CX3CR1 is dysregulated in blood and brain from schizophrenia patients. Schiz Res 168(1–2):434–443 - DOI
    1. Birnbaum R, Jaffe AE, Chen Q, Shin JH, BrainSeq Consortium, Kleinman JE, Hyde TM, Weinberger DR (2018) Investigating the neuroimmunogenic architecture of schizophrenia. Mol Psychiatry 23(5):1251–1260 - PubMed - DOI
    1. Bogerts B, Winopal D, Schwarz S, Schlaaff K, Dobrowolny H, Mawrin C, Frodl T, Steiner J (2017) Evidence of neuroinflammation in subgroups of schizophrenia and mood disorder patients: a semiquantitative postmortem study of CD3 and CD20 immunoreactive lymphocytes in several brain regions. Neurol Psych Brain Res 23:2–9 - DOI
    1. Braun E, Hotter D, Koepke L, Zech F, Groß R, Sparrer KMJ, Müller JA, Pfaller CK, Heusinger E, Wombacher R, Sutter K, Dittmer U, Winkler M, Simmons G, Jakobsen MR, Conzelmann K, Pöhlmann S, Münch J, Fackler OT, Kirchhoff F, Sauter D (2019) Guanylate-binding proteins 2 and 5 exert broad antiviral activity by inhibiting Furin-mediated processing of viral envelope proteins. Cell Rep 27:2092–2104 - PubMed - DOI