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. 2022 Apr 27;8(4):405-407.
doi: 10.1021/acscentsci.2c00369. Epub 2022 Apr 4.

The Path to Paxlovid

Bethany Halford

The Path to Paxlovid

Bethany Halford. ACS Cent Sci. .
No abstract available

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Figures

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Nirmatrelvir (PF-07321332) bound to the main protease of SARS-CoV-2 (binding pocket is outlined in purple; C = yellow, N = dark blue, O = pink, and F = light blue; a histidine side chain is also shown in green and dark blue). Credit: Joy Yang/Pfizer.
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To create the oral COVID-19 antiviral nirmatrelvir (top), Pfizer scientists altered an antiviral compound called PF-00835231 (center) to make it orally bioavailable. They also pursued a benzothiazol-2-yl ketone candidate (bottom) before choosing nirmatrelvir for its better solubility and potential for scale-up. Credit: C&EN.
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