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. 2021 Dec;38(6):768-773.
doi: 10.4067/s0716-10182021000600768.

[Importance of the neutrophil-lymphocyte ratio in its association with mortality in patients with COVID-19: Experience in a health center in Argentina]

[Article in Spanish]
Matías Carreras  1 , Camila Dasque  1 , Mora Stolar  1 , María Noel Parodi  1 , Rocío Nahir Barrios  2 , Yamila Estramiana  1 , María Victoria Gastaldi  1 , Carlos Mouse  1 , José Luis Presas  1 , Lorenzo Marovelli  1 , Ignacio Javier Gandino  1
Affiliations
Free article

[Importance of the neutrophil-lymphocyte ratio in its association with mortality in patients with COVID-19: Experience in a health center in Argentina]

[Article in Spanish]
Matías Carreras et al. Rev Chilena Infectol. 2021 Dec.
Free article

Abstract

Background: COVID-19 rapidly progresses to acute respiratory failure and mortality. A pandemic needs an urgent requirement for low-cost and easy-access tools that assess the infection evolution. The neutrophil-lymphocyte ratio (NLR) is an inflammatory biomarker used in several diseases.

Aim: To estimate the association between NLR > 3 with mortality in hospitalized patients with COVID 19.

Methods: NLR was analyzed in patients with COVID-19 seen at Hospital Fernandez between March and August 2020. Patients were grouped in those with NLR < 3 and those with NLR > 3. Clinical characteristics and mortality were analyzed and compared between groups. A multivariable regression model was used to estimate the association between NLR > 3 and mortality.

Results: We included 711 patients with COVID-19. In a multivariable regression model, NLR > 3 associated with mortality (OR 3.8; 95% CI 1.05 to 13.7; p 0.04) adjusting by age, days of hospitalization, intensive care requirement, severe pneumonia, C-reactive protein levels, arterial hypertension, and comorbidities.

Conclusion: NLR was associated with mortality, and it is an accessible and easy tool to use in the first evaluation of hospitalized patients with COVID-19.

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