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Editorial
. 2022 May 10;119(19):e2204159119.
doi: 10.1073/pnas.2204159119. Epub 2022 May 4.

When the BBB goes MIA

Caroline A Pearson  1 , Costantino Iadecola  1
Affiliations
Editorial

When the BBB goes MIA

Caroline A Pearson et al. Proc Natl Acad Sci U S A. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interest.

Figures

Fig. 1.
Fig. 1.
MIA disrupts the BBB in the offspring. MIA increases inflammatory cytokines in the mother that lead to nonresolving inflammation in the offspring which, in turn, may underlie neurodevelopmental disorders associated with maternal infections (Top). MIA up-regulates COX-2 in microglia, leading to microglial activation, clustering of microglia around blood vessels, endothelial inflammation, pericyte loss, and increased permeability of the BBB in the offspring (Middle). The BBB dysfunction may promote persistent inflammation as well as the entry into the brain parenchyma of blood-derived toxins which may predispose to developmental alterations and neuronal dysfunction (Bottom).
See this image and copyright information in PMC

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References

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