Krebs takes a turn at cell differentiation

Stanisław Deja¹, Peter A Crawford², Shawn C Burgess³

Affiliations

¹ Center for Human Nutrition, The University of Texas Southwestern Medical Center, Dallas, TX, USA; Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
² Division of Molecular Medicine; Department of Medicine, University of Minnesota, Minneapolis, MN, USA.
³ Center for Human Nutrition, The University of Texas Southwestern Medical Center, Dallas, TX, USA; Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address: shawn.burgess@utsouthwestern.edu.

PMID: 35508108
DOI: 10.1016/j.cmet.2022.04.005

Free article

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Krebs takes a turn at cell differentiation

Stanisław Deja et al. Cell Metab. 2022.

Free article

. 2022 May 3;34(5):658-660.

doi: 10.1016/j.cmet.2022.04.005.

Authors

Stanisław Deja¹, Peter A Crawford², Shawn C Burgess³

Affiliations

¹ Center for Human Nutrition, The University of Texas Southwestern Medical Center, Dallas, TX, USA; Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
² Division of Molecular Medicine; Department of Medicine, University of Minnesota, Minneapolis, MN, USA.
³ Center for Human Nutrition, The University of Texas Southwestern Medical Center, Dallas, TX, USA; Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address: shawn.burgess@utsouthwestern.edu.

PMID: 35508108
DOI: 10.1016/j.cmet.2022.04.005

Abstract

In a recent issue of Nature, Arnold et al. report that the partitioning of citrate away from the oxidative steps of the tricarboxylic acid cycle and into the citrate-malate shuttle is essential for mouse embryonic stem cell differentiation. Their findings highlight a crucial role for metabolic regulation in developmental biology.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

A non-canonical tricarboxylic acid cycle underlies cellular identity.
Arnold PK, Jackson BT, Paras KI, Brunner JS, Hart ML, Newsom OJ, Alibeckoff SP, Endress J, Drill E, Sullivan LB, Finley LWS. Arnold PK, et al. Nature. 2022 Mar;603(7901):477-481. doi: 10.1038/s41586-022-04475-w. Epub 2022 Mar 9. Nature. 2022. PMID: 35264789 Free PMC article.

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Krebs takes a turn at cell differentiation

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Krebs takes a turn at cell differentiation

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