. 2022 May 4;12(1):7234.

doi: 10.1038/s41598-022-11375-6.

A comprehensive study on essential oil compositions, antioxidant, anticholinesterase and antityrosinase activities of three Iranian Artemisia species

Saba Shahrivari¹, Saeedeh Alizadeh², Kazem Ghassemi-Golezani³, Elyas Aryakia⁴

Affiliations

¹ Department of Horticultural Sciences, Faculty of Agriculture, University of Tabriz, Tabriz, Iran. saba.shahrivariii@gmail.com.
² Department of Horticultural Sciences, Faculty of Agriculture, University of Tabriz, Tabriz, Iran.
³ Department of Plant Ecophysiology, Faculty of Agriculture, University of Tabriz, Tabriz, Iran.
⁴ Plant Bank, Iranian Biological Resource Center (IBRC) (ACECR), Tehran, Iran.

PMID: 35508595
PMCID: PMC9068787
DOI: 10.1038/s41598-022-11375-6

A comprehensive study on essential oil compositions, antioxidant, anticholinesterase and antityrosinase activities of three Iranian Artemisia species

Saba Shahrivari et al. Sci Rep. 2022.

. 2022 May 4;12(1):7234.

doi: 10.1038/s41598-022-11375-6.

Authors

Saba Shahrivari¹, Saeedeh Alizadeh², Kazem Ghassemi-Golezani³, Elyas Aryakia⁴

Affiliations

¹ Department of Horticultural Sciences, Faculty of Agriculture, University of Tabriz, Tabriz, Iran. saba.shahrivariii@gmail.com.
² Department of Horticultural Sciences, Faculty of Agriculture, University of Tabriz, Tabriz, Iran.
³ Department of Plant Ecophysiology, Faculty of Agriculture, University of Tabriz, Tabriz, Iran.
⁴ Plant Bank, Iranian Biological Resource Center (IBRC) (ACECR), Tehran, Iran.

PMID: 35508595
PMCID: PMC9068787
DOI: 10.1038/s41598-022-11375-6

Abstract

Artemisia is one of the most diverse genera in the Asteraceae family. The genus is wildly distributed in Irano-Turanian habitats and includes 34 species in Iran. Here, for the first time the essential oil variability, antioxidants and anti-cholinesterase and anti-tyrosinase activities of extracts of three Artemisia species (A. tournefortiana, A. khorassanica, A. haussknechtii), from different regions of Iran were evaluated. Based on GC-MS analyses, 81.84% to 98.70% of the total oils were identified. Cluster analysis grouped the studied populations in three different chemotypes. The highest and the lowest essential oil contents were observed in A. khorassanica and A. haussknechtii species, respectively. Camphor, en-in-dicycloether, 1,8-cineole and (Z)-β-farnesene were the dominant components of essential oil in investigated ecotypes. The results revealed that the total phenol content was higher in A. tournefortiana collected from Kerman and A. haussknechtii collected from Chaharmahal and Bakhtiari. However, the lowest phenol content was recorded for A. haussknechtii collected from Isfahan province. The highest flavonoids content was found in A. tournefortiana collected from West Azerbaijan and A. khorassanica collected from North Khorasan. The highest FRAP antioxidant activity was observed in A. tournefortiana (Kerman) and the lower amount was in A. haussknechtii collected from Kohgiluyeh and Boyer-Ahmad. The highest antioxidant activity by DPPH method was in A. khorassanica collected from South Khorasan and the lowest activity was in Isfahan's A. haussknechtii. The acetycholine esterase inhibitory activity was higher in A. tournefortiana collected from West Azerbaijan; and the lowest activity was in A. haussknechtii collected from Chaharmahal and Bakhtiari province. The highest tyrosinase inhibitory activity was in A. khorassanica collected from North Khorasan; and the lowest was in A. haussknechtii collected from Chaharmahal and Bakhtiari.

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Conflict of interest statement

The authors declare no competing interests.

Figures

**Figure 1**
Schematic diagram of the experimental design.

**Figure 2**
Dandrogram of essential oil compounds cluster analysis. E1: *A.tournefortiana* (Kerman province), E2: *A.tournefortiana* (North Khorasan province), E3: *A.tournefortiana* (West Azerbaijan province), E4: *A.khorassanica* (South Khorasan province), E5: *A.khorassanica* (North Khorasan province), E6: *A.khorassanica* (Semnan province), E7: *A.haussknechtii* (Kohgiluyeh and Boyer-Ahmad province), E8: *A.haussknechtii* (Isfahan province), E9: *A.haussknechtii* (Chaharmahal and Bakhtiari province).

**Figure 3**
Comparison of mean total phenol ± standard error in different *Artemisia* ecotypes. E1: *A.tournefortiana* (Kerman province), E2: *A.tournefortiana* (North Khorasan province), E3: *A.tournefortiana* (West Azerbaijan province), E4: *A.khorassanica* (South Khorasan province), E5: *A.khorassanica* (North Khorasan province), E6: *A.khorassanica* (Semnan province), E7: *A.haussknechtii* (Kohgiluyeh and Boyer-Ahmad province), E8: *A.haussknechtii* (Isfahan province), E9: *A.haussknechtii* (Chaharmahal and Bakhtiari province).

**Figure 4**
Comparison of mean total flavonoid ± standard error in different *Artemisia* ecotypes. E1: *A.tournefortiana* (Kerman province), E2: *A.tournefortiana* (North Khorasan province), E3: *A.tournefortiana* (West Azerbaijan province), E4: *A.khorassanica* (South Khorasan province), E5: *A.khorassanica* (North Khorasan province), E6: *A.khorassanica* (Semnan province), E7: *A.haussknechtii* (Kohgiluyeh and Boyer-Ahmad province), E8: *A.haussknechtii* (Isfahan province), E9: *A.haussknechtii* (Chaharmahal and Bakhtiari province).

**Figure 5**
Comparison of mean ± standard error of antioxidant activity of *Artemisia* ecotypes by DPPH method. E1: *A.tournefortiana* (Kerman province), E2: *A.tournefortiana* (North Khorasan province), E3: *A.tournefortiana* (West Azerbaijan province), E4: *A.khorassanica* (South Khorasan province), E5: *A.khorassanica* (North Khorasan province), E6: *A.khorassanica* (Semnan province), E7: *A.haussknechtii* (Kohgiluyeh and Boyer-Ahmad province), E8: *A.haussknechtii* (Isfahan province), E9: *A.haussknechtii* (Chaharmahal and Bakhtiari province).

**Figure 6**
Comparison of mean ± standard error of antioxidant activity by FRAP method. E1: *A.tournefortiana* (Kerman province), E2: *A.tournefortiana* (North Khorasan province), E3: *A.tournefortiana* (West Azerbaijan province), E4: *A.khorassanica* (South Khorasan province), E5: *A.khorassanica* (North Khorasan province), E6: *A.khorassanica* (Semnan province), E7: *A.haussknechtii* (Kohgiluyeh and Boyer-Ahmad province), E8: *A.haussknechtii* (Isfahan province), E9: *A.haussknechtii* (Chaharmahal and Bakhtiari province).

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A comprehensive study on essential oil compositions, antioxidant, anticholinesterase and antityrosinase activities of three Iranian Artemisia species

Affiliations

A comprehensive study on essential oil compositions, antioxidant, anticholinesterase and antityrosinase activities of three Iranian Artemisia species

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

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