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. 2022 Oct;42(10):1368-1373.
doi: 10.1038/s41372-022-01409-2. Epub 2022 May 4.

Impact of quality improvement outreach education on the incidence of acute brain injury in transported neonates born premature

Khorshid Mohammad  1 , Sarfaraz Momin  2 , Prashanth Murthy  2 , Hussein Zein  2 , James N Scott  3 , Ayman Abou Mehrem  2 , Anirban Ghosh  2 , Artem Javadyan  2 , Essa Al Awad  2 , Sujith Kumar Reddy Gurram Venkata  2 , Renee Paul  2 , Bryan Rombough  2 , Leah Bolderheij  2 , Salma Dossani  2 , John Montpetit  2 , Peace Eshemokhai  2 , Elsa Fiedrich  2 , Sumesh Thomas  2
Affiliations

Impact of quality improvement outreach education on the incidence of acute brain injury in transported neonates born premature

Khorshid Mohammad et al. J Perinatol. 2022 Oct.

Abstract

Objective: To evaluate impact of a quality improvement (QI) outreach education on incidence of acute brain injury in transported premature neonates.

Study design: Neonates born at <33 weeks gestation outside the tertiary center were included. The QI intervention was a combination of neuroprotection care bundle, in-person visits, and communication system improvement. Descriptive and regression (adjusting for Gestational Age, Birth Weight, Gender, and antenatal steroids, Mode of delivery, Apgars at 5 minutes, Prophylactic indomethacin, PDA, and Inotropes use) analyses were performed. The primary outcome was a composite of death and/or severe brain injury on cranial ultrasound using a validated classification.

Results: 181 neonates studied (93 before and 88 after). The rate and adjusted odds of death and/or severe brain injury reduced significantly post intervention (30% vs 15%) and (AOR 0.36, 95%CI, 0.15-0.85, P = 0.02) respectively.

Conclusion: Implementation of outreach education targeting neuroprotection can reduce acute brain injury in transported premature neonates.

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References

    1. Calisici E, Eras Z, Oncel MY, Oguz SS, Gokce IK, Dilmen U. Neurodevelopmental outcomes of premature infants with severe intraventricular hemorrhage. J Matern Fetal Neonatal Med. 2015;28:2115–20. - DOI
    1. Leijser LM, de Vries LS. Preterm brain injury: germinal matrix-intraventricular hemorrhage and post-hemorrhagic ventricular dilatation. Handb Clin Neurol. 2019;162:173–99. - DOI
    1. Synnes A, Luu TM, Moddemann D, Church P, Lee D, Vincer M, et al. Determinants of developmental outcomes in a very preterm Canadian cohort. Arch Dis Child Fetal Neonatal Ed. 2017;102:F235–F234. - DOI
    1. van Zanten SA, de Haan TR, Ursum J, van Sonderen L. Neurodevelopmental outcome of post-hemorrhagic ventricular dilatation at 12 and 24 months corrected age with high-threshold therapy. Eur J Paediatr Neurol. 2011;15:487–92. - DOI
    1. Diwakar K, Hader WJ, Soraisham A, Amin H, Tang S, Bullivant K, et al. Long-term neurodevelopmental and growth outcomes of premature infants born at <29 week gestational age with post-hemorrhagic hydrocephalus treated with ventriculo-peritoneal shunt. Indian J Pediatr. 2017;84:662–9. - DOI

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