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. 2022 Mar 15;13(15):4327-4333.
doi: 10.1039/d2sc00968d. eCollection 2022 Apr 13.

Catalytic alkene skeletal modification for the construction of fluorinated tertiary stereocenters

Liyin Jiang  1 , Pau Sarró  1   2 , Wei Jie Teo  1 , Jordi Llop  3 , Marcos G Suero  1
Affiliations

Catalytic alkene skeletal modification for the construction of fluorinated tertiary stereocenters

Liyin Jiang et al. Chem Sci. .

Abstract

Herein we describe the first construction of fluorinated tertiary stereocenters based on an alkene C(sp2)-C(sp2) bond cleavage. The new process, that takes advantage of a Rh-catalyzed carbyne transfer, relies on a branched-selective fluorination of tertiary allyl cations and is distinguished by a wide scope including natural products and drug molecule derivatives as well as adaptability to radiofluorination.

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Conflict of interest statement

There are no conflicts to declare.

Figures

Fig. 1
Fig. 1. Fluorinated tertiary stereocenters.
See this image and copyright information in PMC

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