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. 2022 Mar 31;14(3):e23691.
doi: 10.7759/cureus.23691. eCollection 2022 Mar.

Haematological, Biochemical, and Inflammatory Biomarkers of COVID-19 Patients Hospitalized in Critical Unit: A Retrospective Study

Radi T Alsafi  1 , Faisal Minshawi  1 , Ahmad Alshareef  2 , Essa Althobiany  3 , Afnan Alqurashi  4 , Ayat Zawawi  5 , Ahmed Qasem  1 , Amr J Halawani  1 , Mohammed Almatrafi  6 , Hassan Alwafi  7 , Mohammed Samannodi  8 , Emad Salawati  9 , Hamza M Assaggaf  1
Affiliations

Haematological, Biochemical, and Inflammatory Biomarkers of COVID-19 Patients Hospitalized in Critical Unit: A Retrospective Study

Radi T Alsafi et al. Cureus. .

Abstract

Background: The World Health Organization declared coronavirus disease 2019 (COVID-19) responsible for a catastrophic global pandemic. The complexity of COVID-19 is centred on the unpredictable course of the disease, which can rapidly develop from patients being asymptomatic to having life-threatening symptoms. The unpredictable disease severity of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been a major problem facing the healthcare system during the pandemic. Identifying the laboratory biomarkers would help predict SARS-CoV-2 pathogenicity. This study focused on the previous literature regarding three laboratory biomarker profiles: haematological, inflammatory, and biochemical biomarkers.

Methods: A retrospective study of COVID-19 patients was conducted between May 2020 and September 2020 to determine the predictors of hospitalization (severity) in COVID-19 patients. Patients were divided into two groups: those admitted to an intensive care unit (ICU, severe) and those admitted to a non-ICU (stable). Patients' data were obtained from their medical records at Al Noor Specialist Hospital and East Arafat Hospital in Saudi Arabia.

Results: A total of 487 patients with COVID-19, including 304 males and 183 females, were investigated in this study. A total of 217 patients were admitted to the ICU. Patients admitted to the ICU had a higher prevalence of chronic comorbidities than non-ICU patients. D-dimer, white blood cells (WBC), neutrophils, ferritin, C-reactive protein (CRP), lactate dehydrogenase (LDH), alanine aminotransferase (ALT), and aspartate aminotransferase (AST) were more elevated in patients admitted to the ICU compared to non-ICU patients.

Conclusion: Chronic comorbidities are a significant predictor for admission to the ICU. Moreover, tests for D-dimer, WBC, neutrophils, lymphocytes, CRP, LDH, and ALT could be used to predict patients' admission to the ICU.

Keywords: chronic comorbidities; covid-19; icu; inflammatory biomarkers; sars-cov-2.

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Conflict of interest statement

The authors have declared that no competing interests exist.

References

    1. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lu R, Zhao X, Li J, et al. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(20)30251.... Lancet. 2020;395:565–574. - PMC - PubMed
    1. A novel coronavirus from patients with pneumonia in China, 2019. Zhu N, Zhang D, Wang W, et al. https://www.nejm.org/doi/full/10.1056/nejmoa2001017. N Engl J Med. 2020;382:727–733. - PMC - PubMed
    1. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Chen N, Zhou M, Dong X, et al. https://www.sciencedirect.com/science/article/pii/S0140673620302117. Lancet. 2020;395:507–513. - PMC - PubMed
    1. Analysis of related factors of brittle hip fracture in postmenopausal women with osteoporosis. Zhuang HF, Wang PW, Li YZ, Lin JK, Yao XD, Xu H. https://onlinelibrary.wiley.com/doi/full/10.1111/os.12605. Orthop Surg. 2020;12:194–198. - PMC - PubMed
    1. Laboratory biomarkers of COVID-19 disease severity and outcome: findings from a developing country. Leulseged TW, Hassen IS, Ayele BT, et al. PLoS One. 2021;16:0. - PMC - PubMed

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