Antibody response to three SARS-CoV-2 mRNA vaccines in adolescent solid organ transplant recipients

Caroline X Qin^{1

2}, Scott R Auerbach³, Olga Charnaya⁴, Lara A Danziger-Isakov⁵, Noelle H Ebel⁶, Amy G Feldman⁷, Evelyn K Hsu⁸, John McAteer^{4

9}, Saeed Mohammad¹⁰, Emily R Perito¹¹, Ashley M Thomas¹, Teresa P Y Chiang², Jacqueline M Garonzik-Wang¹², Dorry L Segev^{2

13}, Douglas B Mogul¹

Affiliations

¹ Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Johns Hopkins Children's Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
² Department of Surgery, The Johns Hopkins Hospital, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
³ Division of Cardiology, Department of Pediatrics, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, Colorado, USA.
⁴ Division of Nephrology, Department of Pediatrics, Johns Hopkins Children's Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
⁵ Division of Infectious Diseases, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
⁶ Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Lucile Packard Children's Hospital Stanford, Stanford University School of Medicine, Palo Alto, California, USA.
⁷ Section of Gastroenterology, Hepatology and Nutrition, Digestive Health Institute, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, Colorado, USA.
⁸ Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Seattle Children's Hospital, University of Washington School of Medicine, Seattle, Washington, USA.
⁹ Division of Infectious Diseases, Department of Pediatrics, Johns Hopkins Children's Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
¹⁰ Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
¹¹ Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of California San Francisco Benioff Children's Hospital, University of California San Francisco School of Medicine, San Francisco, California, USA.
¹² Department of Surgery, University of Wisconsin Health University Hospital, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
¹³ Department of Surgery, New York University Langone Health, New York University Grossman School of Medicine, New York, New York, USA.

PMID: 35510786
PMCID: PMC9348453
DOI: 10.1111/ajt.17085

Antibody response to three SARS-CoV-2 mRNA vaccines in adolescent solid organ transplant recipients

Caroline X Qin et al. Am J Transplant. 2022 Oct.

. 2022 Oct;22(10):2481-2483.

doi: 10.1111/ajt.17085. Epub 2022 May 13.

Authors

Affiliations

¹ Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Johns Hopkins Children's Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
² Department of Surgery, The Johns Hopkins Hospital, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
³ Division of Cardiology, Department of Pediatrics, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, Colorado, USA.
⁴ Division of Nephrology, Department of Pediatrics, Johns Hopkins Children's Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
⁵ Division of Infectious Diseases, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
⁶ Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Lucile Packard Children's Hospital Stanford, Stanford University School of Medicine, Palo Alto, California, USA.
⁷ Section of Gastroenterology, Hepatology and Nutrition, Digestive Health Institute, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, Colorado, USA.
⁸ Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Seattle Children's Hospital, University of Washington School of Medicine, Seattle, Washington, USA.
⁹ Division of Infectious Diseases, Department of Pediatrics, Johns Hopkins Children's Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
¹⁰ Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
¹¹ Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of California San Francisco Benioff Children's Hospital, University of California San Francisco School of Medicine, San Francisco, California, USA.
¹² Department of Surgery, University of Wisconsin Health University Hospital, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
¹³ Department of Surgery, New York University Langone Health, New York University Grossman School of Medicine, New York, New York, USA.

PMID: 35510786
PMCID: PMC9348453
DOI: 10.1111/ajt.17085

No abstract available

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Figures

**FIGURE 1**
Pre-dose 3, 1 month post-dose 3, and 3 months post-dose 3 antibody titers among adolescent SOTRs. Samples were available for 43 participants pre-D3 (32 positive, 11 negative), 43 participants 1 month post-D3 (38 positive, 5 negative), and 31 participants 3 months post-D3 (28 positive, 3 negative). Dark blue circles and lines represent antibody titer trends of participants with positive pre-D3 titers (n = 32), and yellow circles and lines represent antibody titer trends of participants with negative pre-D3 titers (n = 11). Participants who reported past SARS-CoV-2 infection prior to receiving dose 1 (n = 4) are marked by light blue triangles. Jittered and darker shapes and lines represent multiple participants. Participants who reported breakthrough SARS-CoV-2 infections during the study period are not distinguished in this Figure. Participant samples were processed using the qualitative and semi-quantitative Roche Elecsys anti-SARS-CoV-2 S enzyme immunoassay that tests for total antibody against the receptor-binding domain of the SARS-CoV-2 spike protein. Per the manufacturer, a positive threshold of ≥0.8 U/mL was used. The minimum titer reported by the assay is <0.8 U/ml and the maximum titer is >2500 U/ml. 6/11 participants with negative pre-D3 titers seroconverted to have positive 1 month post-D3 titers, while 5/11 participants remained seronegative. 19/32 participants had positive pre-D3 titers lower than the assay’s maximum titer, of which 2/19 had their 1 month post-D3 titer increase by 1600–1800 U/ml and 17/19 had their 1 month post-D3 titer increase to the assay’s maximum. 13/32 participants with positive pre-D3 titers at the assay’s maximum titer continued to have 1 month post-D3 titers of >2500 U/ml. Among participants with 3 month post-D3 samples, 27/31 with positive 1 month post-D3 titers remained seropositive, 3/31 with negative 1 month post-D3 titers remained seronegative, and 1/31 with negative 1 month post-D3 titer and pre-D3 breakthrough SARS-CoV-2 infection seroconverted to have a positive 3 months post-D3 titer

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References

1. Qin CX, Auerbach SR, Charnaya O, et al. Antibody response to 2-dose SARS-CoV-2 mRNA vaccination in pediatric solid organ transplant recipients. Am J Transplant. 2022;22(2):669–672. - PMC - PubMed
1. Haskin O, Ashkenazi-Hoffnung L, Ziv N, et al. Serological response to the BNT162b2 COVID-19 mRNA vaccine in adolescent and young adult kidney transplant recipients. Transplantation. 2021;105(11):e226–e233. - PMC - PubMed
1. Kamar N, Abravanel F, Marion O, Couat C, Izopet J, Del Bello A. Three doses of an mRNA Covid-19 vaccine in solid-organ transplant recipients. N Engl J Med. 2021;385(7):661–662. - PMC - PubMed
1. Karaba AH, Zhu X, Liang T, et al. A third dose of SARS-CoV-2 vaccine increases neutralizing antibodies against variants of concern in solid organ transplant recipients. Am J Transplant. 2022;22(4):1253–1260. - PMC - PubMed
1. Roche Diagnostics. Elecsys® Anti-SARS-CoV-2 S. https://diagnostics.roche.com/us/en/products/params/elecsys-anti-sars-co.... Accessed August 11, 2021.

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Antibody response to three SARS-CoV-2 mRNA vaccines in adolescent solid organ transplant recipients

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Antibody response to three SARS-CoV-2 mRNA vaccines in adolescent solid organ transplant recipients

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