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. 2023 May 1;42(3):301-307.
doi: 10.1097/PGP.0000000000000886. Epub 2022 Apr 12.

The Presence of the Autophagic Markers LC3B and Sequestosome 1/p62 in the Hydatidiform Mole

Georgia Karpathiou, Maroa Dridi, Alexandra Papoudou-Bai, Marine Perard, Alix Clemenson, Celine Chauleur, Michel Peoc'h

The Presence of the Autophagic Markers LC3B and Sequestosome 1/p62 in the Hydatidiform Mole

Georgia Karpathiou et al. Int J Gynecol Pathol. .

Abstract

Autophagy is implicated in normal pregnancy and various pathologic pregnancy conditions. Its presence in hydatidiform moles (HM) is unknown. We immunohistochemically studied 36 HM for LC3B and p62 to precisely determine their expression in the decidua, endometrium, and villi. Nineteen nonmolar pregnancies were also studied. LC3B was found in almost half of the villi and p62 was found in almost all villi. LC3B expression was significantly higher in complete HM than in partial HM. LC3B showed different expression patterns in trophoblast layers. LC3B and p62 expression was higher in molar than nonmolar pregnancies. Autophagic markers are present in HM and their expression differs between complete and partial moles.

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Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Tantengco OAG, De Jesus FCC, Gampoy EFS, et al. Molar pregnancy in the last 50 years: a bibliometric analysis of global research output. Placenta 2021;112:54–61.
    1. Hui P, Shih I WHO Classification of Tumours Editorial Board. Gestational trophoblastic disease: introduction. WHO Classification of Female Genital Tumours, 5th ed. Lyon, France: International Agency for Research on Cancer; 2020:310.
    1. Buza N, Colgan T, Sebire N, et al. WHO Classification of Tumours Editorial Board. Complete hydatidiform mole. WHO Classification of Female Genital Tumours, 5th ed. Lyon, France: International Agency for Research on Cancer; 2020:319–21.
    1. Buza N, Colgan T, Sebire N, et al. . Partial hydatidiform mole. WHO Classification of Female Genital Tumours, 5th ed. Lyon, France: International Agency for Research on Cancer; 2020:317–8.
    1. Oh S, Roh C-R. Autophagy in the placenta. Obstet Gynecol Sci 2017;60:241.