Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1978 Jul;35(1):151-7.

Direct blockade of antigen-reactive B lymphocytes by immune complexes. An 'off' signal for precursors of IgM-producing cells provided by the linkage of antigen-and Fc-receptors

J Oberbarnscheidt, E Kölsch

Direct blockade of antigen-reactive B lymphocytes by immune complexes. An 'off' signal for precursors of IgM-producing cells provided by the linkage of antigen-and Fc-receptors

J Oberbarnscheidt et al. Immunology. 1978 Jul.

Abstract

Antigen-antibody complexes efficiently inhibit the induction of antibody formation. Using Mishell-Dutton cultures, it can be demonstrated that neither T cells nor their products are required for this inhibition of IgM PFC formation. The blockade is at the level of B cells and cannot be overcome by LPS or TRF. The data demonstrate that cross-linking of antigen- and Fc-receptors by antigen-antibody complexes is a blocking signal for B cells.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. J Exp Med. 1965 Jun 1;121:969-89 - PubMed
    1. J Immunol. 1977 Apr;118(4):1213-8 - PubMed
    1. J Exp Med. 1976 Oct 1;144(4):882-96 - PubMed
    1. Eur J Immunol. 1976 Jan;6(1):63-8 - PubMed
    1. J Immunol Methods. 1974 Aug;5(3):239-47 - PubMed

LinkOut - more resources