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Comment
. 2022 May 4;110(9):1446-1449.
doi: 10.1016/j.neuron.2022.04.018.

Brain-behavior correlations: Two paths toward reliability

Caterina Gratton  1 , Steven M Nelson  2 , Evan M Gordon  3
Affiliations
Free article
Comment

Brain-behavior correlations: Two paths toward reliability

Caterina Gratton et al. Neuron. .
Free article

Abstract

In a recent issue of Nature, Marek et al. (2022) demonstrate that cross-sectional brain-behavior correlations are often small and unreliable without large samples. This observation pushes human neuroscience toward study designs that either maximize sample sizes to detect small effects or maximize effect sizes using focused investigations.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

  • Reproducible brain-wide association studies require thousands of individuals.
    Marek S, Tervo-Clemmens B, Calabro FJ, Montez DF, Kay BP, Hatoum AS, Donohue MR, Foran W, Miller RL, Hendrickson TJ, Malone SM, Kandala S, Feczko E, Miranda-Dominguez O, Graham AM, Earl EA, Perrone AJ, Cordova M, Doyle O, Moore LA, Conan GM, Uriarte J, Snider K, Lynch BJ, Wilgenbusch JC, Pengo T, Tam A, Chen J, Newbold DJ, Zheng A, Seider NA, Van AN, Metoki A, Chauvin RJ, Laumann TO, Greene DJ, Petersen SE, Garavan H, Thompson WK, Nichols TE, Yeo BTT, Barch DM, Luna B, Fair DA, Dosenbach NUF. Marek S, et al. Nature. 2022 Mar;603(7902):654-660. doi: 10.1038/s41586-022-04492-9. Epub 2022 Mar 16. Nature. 2022. PMID: 35296861 Free PMC article.

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