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. 2022 Jul-Aug:59:107429.
doi: 10.1016/j.carpath.2022.107429. Epub 2022 May 3.

"Role of Cardiac Inflammation in the Pathology of COVID-19; relationship to the current definition of myocarditis"

Sharon E Fox  1 , R S Vander Heide  2
Affiliations

"Role of Cardiac Inflammation in the Pathology of COVID-19; relationship to the current definition of myocarditis"

Sharon E Fox et al. Cardiovasc Pathol. 2022 Jul-Aug.
No abstract available

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Figures

Fig 1
Fig. 1
Diagram outlining author’s current hypothesis regarding COVID-19 related cardiac pathophysiology.Blue arrows indicate pathways with experimental and/or clinical support. Red arrows indicate pathways proposed by the authors. Endothelial damage/dysfunction is key to acute cardiac injury in severe COVID infection. Macrophages/CD68+ cells are hypothesized to be important mediators of cardiac inflammation as well as contributors to potential PASC/Long COVID effects.
See this image and copyright information in PMC

References

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    1. Pellegrini D, Kawakami R, Guagliumi G, Sakamoto A, Kawai K, Gianatti A, et al. Microthrombi as a major cause of cardiac injury in COVID-19: A pathologic study. Circulation. 2021;143(10):1031–1042. doi: 10.1161/CIRCULATIONAHA.120.051828. doi:Epub 2021 Jan 22. PMID: 33480806. - DOI - PubMed
    1. Fox SE, Li G, Akmatbekov A, Harbert JL, Lameira FS, Brown JQ, et al. Unexpected features of cardiac pathology in COVID-19 infection. Circulation. 2020;142(11):1123–1125. doi: 10.1161/CIRCULATIONAHA.120.049465. doi:Epub 2020 Jul 21. PMID: 32689809. - DOI - PubMed
    1. Fox SE, Falgout L, Vander Heide RS. COVID-19 myocarditis: quantitative analysis of the inflammatory infiltrate and a proposed mechanism. Cardiovasc Pathol. 2021;54 doi: 10.1016/j.carpath.2021.107361. doi:Epub 2021 Jun 24. PMID: 34174415; PMCID: PMC8223028. - DOI - PMC - PubMed