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. 2022 Jul-Aug:59:107429.
doi: 10.1016/j.carpath.2022.107429. Epub 2022 May 3.

"Role of Cardiac Inflammation in the Pathology of COVID-19; relationship to the current definition of myocarditis"

Sharon E Fox  1 , R S Vander Heide  2
Affiliations

"Role of Cardiac Inflammation in the Pathology of COVID-19; relationship to the current definition of myocarditis"

Sharon E Fox et al. Cardiovasc Pathol. 2022 Jul-Aug.
No abstract available

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Figures

Fig 1
Fig. 1
Diagram outlining author’s current hypothesis regarding COVID-19 related cardiac pathophysiology.Blue arrows indicate pathways with experimental and/or clinical support. Red arrows indicate pathways proposed by the authors. Endothelial damage/dysfunction is key to acute cardiac injury in severe COVID infection. Macrophages/CD68+ cells are hypothesized to be important mediators of cardiac inflammation as well as contributors to potential PASC/Long COVID effects.
See this image and copyright information in PMC

References

    1. Fox SE, Akmatbekov A, Harbert JL, Li G, Brown JQ, Vander Heide RS. Pulmonary and cardiac pathology in African American patients with COVID-19: an autopsy series from New Orleans. The Lancet Respiratory Medicine. 2020;8(7):681–686. doi: 10.1016/S2213-2600(20)30243-5. doi: - DOI - PMC - PubMed
    1. Basso C, Leone O, Rizzo S, De Gaspari M, van der Wal AC, Aubry MC, et al. Pathological features of COVID-19-associated myocardial injury: a multicentre cardiovascular pathology study. Eur Heart J. 2020;41(39):3827–3835. doi: 10.1093/eurheartj/ehaa664. doi:PMID: 32968776; PMCID: PMC7543528. - DOI - PMC - PubMed
    1. Pellegrini D, Kawakami R, Guagliumi G, Sakamoto A, Kawai K, Gianatti A, et al. Microthrombi as a major cause of cardiac injury in COVID-19: A pathologic study. Circulation. 2021;143(10):1031–1042. doi: 10.1161/CIRCULATIONAHA.120.051828. doi:Epub 2021 Jan 22. PMID: 33480806. - DOI - PubMed
    1. Fox SE, Li G, Akmatbekov A, Harbert JL, Lameira FS, Brown JQ, et al. Unexpected features of cardiac pathology in COVID-19 infection. Circulation. 2020;142(11):1123–1125. doi: 10.1161/CIRCULATIONAHA.120.049465. doi:Epub 2020 Jul 21. PMID: 32689809. - DOI - PubMed
    1. Fox SE, Falgout L, Vander Heide RS. COVID-19 myocarditis: quantitative analysis of the inflammatory infiltrate and a proposed mechanism. Cardiovasc Pathol. 2021;54 doi: 10.1016/j.carpath.2021.107361. doi:Epub 2021 Jun 24. PMID: 34174415; PMCID: PMC8223028. - DOI - PMC - PubMed

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