A comparison of Sars-Cov-2 vaccine platforms: the CoviCompare project

Diana Molino¹, Christine Durier², Anne Radenne³, Corinne Desaint², Jacques Ropers³, Soizic Courcier¹, Louis Victorien Vieillard¹, Claire Rekacewicz¹, Beatrice Parfait⁴, Victor Appay⁵, Frédéric Batteux⁶, Emmanuel Barillot⁷, Michel Cogné⁸, Béhazine Combadière⁹, Christiane S Eberhardt¹⁰, Guy Gorochov¹¹, Philippe Hupé^{7

12}, Laetitia Ninove¹³, Stéphane Paul¹⁴, Isabelle Pellegrin⁵, Sylvie van der Werf¹⁵, Maeva Lefebvre¹⁶, Elisabeth Botelho-Nevers¹⁷, Inmaculada Ortega-Perez¹⁸, Marie Jaspard^{19

20}, Samba Sow²¹, Jean Daniel Lelièvre²², Xavier de Lamballerie¹³, Marie Paule Kieny²³, Eric Tartour²⁴, Odile Launay²⁵

Affiliations

¹ Université Paris Cité, National Institute for Health and Medical Research (INSERM) CIC 1417 Cochin Pasteur, Innovative Clinical Research Network in Vaccinology (I-REIVAC), Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Cochin, Paris, France.
² INSERM SC10-US019, Villejuif, France.
³ AP-HP, Hôpitaux Universitaires Pitié Salpêtrière-Charles Foix, Unité de Recherche Clinique des Hôpitaux Universitaires Pitié Salpêtrière, Paris, France.
⁴ AP-HP, Hôpital Cochin, Fédération des Centres de Ressources Biologiques-Plateforme de Ressources Biologiques Centre de Ressources Biologique Cochin, Paris, France.
⁵ Centre Hospitalier Universitaire (CHU) Bordeaux, Laboratory of Immunology and Immunogenetics, Université de Bordeaux, Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) 5164, INSERM ERL 1303, ImmunoConcEpT, Bordeaux, France.
⁶ AP-HP, Hôpital Cochin, Service d'Immunologie Biologique et Plateforme d'Immunomonitoring Vaccinal, Paris, France.
⁷ Institut Curie, PSL Research University-INSERM U900-MINES ParisTech, PSL, Paris, France.
⁸ Laboratory of Immunology-Research Unit INSERM U 1236, B cell Ig Remodelling Singularities (BIGRES), Faculty of Medicine, French Blood Center (EFS Bretagne) & University Hospital, Rennes, France.
⁹ Centre d'Immunologie et des Maladies Infectieuses-Paris (Cimi-Paris), INSERM U1135, Sorbonne Université, Paris, France.
¹⁰ University of Geneva, Faculty of Medicine, Division of General Pediatrics, Department of Woman, Child and Adolescent Medicine and Center for Vaccinology, Geneva, Switzerland.
¹¹ Sorbonne Université, INSERM, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), Département d'Immunologie, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France.
¹² CNRS, UMR 144, Paris, France.
¹³ Aix Marseille Université, Research Institute for Sustainable Development (IRD) 190, INSERM 1207, IHU Méditerranée Infection, Unité des Virus Émergents, Marseille, France.
¹⁴ INSERM, U1111, CNRS, UMR 530, Immunology and Immunomonitoring Laboratory, iBiothera, CIRI-GIMAP, UCBL 1, UJM, CIC 1408, Saint-Etienne, France.
¹⁵ Université Paris Cité, Institut Pasteur, Unité Génétique Moléculaire Virus à ARN UMR 3569 CNRS, Paris, France.
¹⁶ CHU de Nantes, INSERM CIC1413, Maladies Infectieuses et Tropicales, Centre de Prévention des Maladies Infectieuses et Transmissibles, Nantes, France.
¹⁷ INSERM CIC 1408, Axe Vaccinologie, CHU de Saint-Etienne, Service d'Infectiologie, Saint-Etienne, France.
¹⁸ ANRS | Emerging Infectious Diseases, Paris, France.
¹⁹ The Alliance for International Medical Action (ALIMA), Paris, France.
²⁰ University of Bordeaux, INSERM, IRD, Bordeaux Population Health Center, UMR 1219, Bordeaux, France.
²¹ The Center for Vaccine Development, Bamako, Mali.
²² INSERM U955, Créteil, France, Vaccine research Institute, Créteil, France.
²³ INSERM 101, Paris, France.
²⁴ AP-HP, Hôpital Européen Georges Pompidou, INSERM U970, PARCC, Paris, France.
²⁵ Université Paris Cité, National Institute for Health and Medical Research (INSERM) CIC 1417 Cochin Pasteur, Innovative Clinical Research Network in Vaccinology (I-REIVAC), Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Cochin, Paris, France. odile.launay@aphp.fr.

PMID: 35513532
DOI: 10.1038/s41591-022-01785-4

Free article

A comparison of Sars-Cov-2 vaccine platforms: the CoviCompare project

Diana Molino et al. Nat Med. 2022 May.

Free article

. 2022 May;28(5):882-884.

doi: 10.1038/s41591-022-01785-4.

Authors

Affiliations

¹ Université Paris Cité, National Institute for Health and Medical Research (INSERM) CIC 1417 Cochin Pasteur, Innovative Clinical Research Network in Vaccinology (I-REIVAC), Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Cochin, Paris, France.
² INSERM SC10-US019, Villejuif, France.
³ AP-HP, Hôpitaux Universitaires Pitié Salpêtrière-Charles Foix, Unité de Recherche Clinique des Hôpitaux Universitaires Pitié Salpêtrière, Paris, France.
⁴ AP-HP, Hôpital Cochin, Fédération des Centres de Ressources Biologiques-Plateforme de Ressources Biologiques Centre de Ressources Biologique Cochin, Paris, France.
⁵ Centre Hospitalier Universitaire (CHU) Bordeaux, Laboratory of Immunology and Immunogenetics, Université de Bordeaux, Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche (UMR) 5164, INSERM ERL 1303, ImmunoConcEpT, Bordeaux, France.
⁶ AP-HP, Hôpital Cochin, Service d'Immunologie Biologique et Plateforme d'Immunomonitoring Vaccinal, Paris, France.
⁷ Institut Curie, PSL Research University-INSERM U900-MINES ParisTech, PSL, Paris, France.
⁸ Laboratory of Immunology-Research Unit INSERM U 1236, B cell Ig Remodelling Singularities (BIGRES), Faculty of Medicine, French Blood Center (EFS Bretagne) & University Hospital, Rennes, France.
⁹ Centre d'Immunologie et des Maladies Infectieuses-Paris (Cimi-Paris), INSERM U1135, Sorbonne Université, Paris, France.
¹⁰ University of Geneva, Faculty of Medicine, Division of General Pediatrics, Department of Woman, Child and Adolescent Medicine and Center for Vaccinology, Geneva, Switzerland.
¹¹ Sorbonne Université, INSERM, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), Département d'Immunologie, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France.
¹² CNRS, UMR 144, Paris, France.
¹³ Aix Marseille Université, Research Institute for Sustainable Development (IRD) 190, INSERM 1207, IHU Méditerranée Infection, Unité des Virus Émergents, Marseille, France.
¹⁴ INSERM, U1111, CNRS, UMR 530, Immunology and Immunomonitoring Laboratory, iBiothera, CIRI-GIMAP, UCBL 1, UJM, CIC 1408, Saint-Etienne, France.
¹⁵ Université Paris Cité, Institut Pasteur, Unité Génétique Moléculaire Virus à ARN UMR 3569 CNRS, Paris, France.
¹⁶ CHU de Nantes, INSERM CIC1413, Maladies Infectieuses et Tropicales, Centre de Prévention des Maladies Infectieuses et Transmissibles, Nantes, France.
¹⁷ INSERM CIC 1408, Axe Vaccinologie, CHU de Saint-Etienne, Service d'Infectiologie, Saint-Etienne, France.
¹⁸ ANRS | Emerging Infectious Diseases, Paris, France.
¹⁹ The Alliance for International Medical Action (ALIMA), Paris, France.
²⁰ University of Bordeaux, INSERM, IRD, Bordeaux Population Health Center, UMR 1219, Bordeaux, France.
²¹ The Center for Vaccine Development, Bamako, Mali.
²² INSERM U955, Créteil, France, Vaccine research Institute, Créteil, France.
²³ INSERM 101, Paris, France.
²⁴ AP-HP, Hôpital Européen Georges Pompidou, INSERM U970, PARCC, Paris, France.
²⁵ Université Paris Cité, National Institute for Health and Medical Research (INSERM) CIC 1417 Cochin Pasteur, Innovative Clinical Research Network in Vaccinology (I-REIVAC), Assistance Publique-Hôpitaux de Paris (AP-HP), Hôpital Cochin, Paris, France. odile.launay@aphp.fr.

PMID: 35513532
DOI: 10.1038/s41591-022-01785-4

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A comparison of Sars-Cov-2 vaccine platforms: the CoviCompare project

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A comparison of Sars-Cov-2 vaccine platforms: the CoviCompare project

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