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Editorial
. 2022 Jun;48(6):728-731.
doi: 10.1007/s00134-022-06698-x. Epub 2022 May 5.

In search of the Holy Grail: identifying the best PEEP in ventilated patients

Luciano Gattinoni  1 , John J Marini  2
Affiliations
Editorial

In search of the Holy Grail: identifying the best PEEP in ventilated patients

Luciano Gattinoni et al. Intensive Care Med. 2022 Jun.
No abstract available

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Fig. 1
Fig. 1
The first proposal to identify best PEEP [2] included the simultaneous assessment of oxygenation, respiratory mechanics, and hemodynamics. Afterward, indicators of oxygenation [3], sometimes coupled to hemodynamics [4], were proposed as the key target. The volume–pressure curve was subsequently investigated extensively [7]. In the era of lung protective strategies belong the PEEP table [6] and the stress index. Several present-day proposals include setting PEEP that limits driving and plateau pressures, utilizing dual ‘before and after PEEP increment’ volume–pressure curves [18], and assessing response to a PEEP change with a variety of tools: the ratio of estimated recruited volume to the total volume increment [19], CT scan, bedside lung ultrasound (LUS) or electrical impedance tomography (EIT)
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References

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