Polygenic risk scores for CARDINAL study

Clement A Adebamowo^{1

2}, Adebowale Adeyemo³, Adeyinka Ashaye⁴, Onoja M Akpa⁵, Tinashe Chikowore⁶, Ananyo Choudhury⁶, Yasmina J Fakim⁷, Segun Fatumo^{8

9}, Neil Hanchard³, Michael Hauser¹⁰, Braxton Mitchell¹¹, Nicola Mulder¹², Solomon F Ofori-Acquah^{13

14}, Mayowa Owolabi¹⁵, Michèle Ramsay⁶, Bamidele Tayo¹⁶, Archana Bhavani VasanthKumar¹, Yuji Zhang^{2

17}, Sally N Adebamowo^{18

19}

Affiliations

¹ Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, USA.
² University of Maryland Marlene and Stewart Greenbaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, MD, USA.
³ National Human Genome Research Institute, Rockville, MD, USA.
⁴ Department of Ophthalmology, University of Ibadan, Ibadan, Nigeria.
⁵ Department of Epidemiology and Medical Statistics, University of Ibadan, Ibadan, Nigeria.
⁶ Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
⁷ Department of Biotechnology, University of Mauritius, Reduit, MU, Mauritius.
⁸ The African Computational Genomics (TACG) Research Group, MRC/UVRI and LSHTM (Uganda Research Unit), Entebbe, Uganda.
⁹ London School of Hygiene and Tropical Medicine, London, UK.
¹⁰ Department of Medicine, Duke University, Durham, NC, USA.
¹¹ Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
¹² Computational Biology Division, IDM, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
¹³ West African Genetic Medicine Centre (WAGMC), University of Ghana, Accra, Ghana.
¹⁴ Center for Translational and International Hematology, Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, USA.
¹⁵ Department of Medicine and Center for Genomic and Precision Medicine, University of Ibadan, Ibadan, Nigeria.
¹⁶ Department of Public Health Sciences, Loyola University Chicago, Maywood, IL, USA.
¹⁷ Division of Biostatistics and Bioinformatics, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, USA.
¹⁸ Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, USA. sadebamowo@som.umaryland.edu.
¹⁹ University of Maryland Marlene and Stewart Greenbaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, MD, USA. sadebamowo@som.umaryland.edu.

PMID: 35513726
PMCID: PMC9907721
DOI: 10.1038/s41588-022-01074-3

Polygenic risk scores for CARDINAL study

Clement A Adebamowo et al. Nat Genet. 2022 May.

. 2022 May;54(5):527-530.

doi: 10.1038/s41588-022-01074-3.

Authors

Affiliations

¹ Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, USA.
² University of Maryland Marlene and Stewart Greenbaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, MD, USA.
³ National Human Genome Research Institute, Rockville, MD, USA.
⁴ Department of Ophthalmology, University of Ibadan, Ibadan, Nigeria.
⁵ Department of Epidemiology and Medical Statistics, University of Ibadan, Ibadan, Nigeria.
⁶ Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
⁷ Department of Biotechnology, University of Mauritius, Reduit, MU, Mauritius.
⁸ The African Computational Genomics (TACG) Research Group, MRC/UVRI and LSHTM (Uganda Research Unit), Entebbe, Uganda.
⁹ London School of Hygiene and Tropical Medicine, London, UK.
¹⁰ Department of Medicine, Duke University, Durham, NC, USA.
¹¹ Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
¹² Computational Biology Division, IDM, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
¹³ West African Genetic Medicine Centre (WAGMC), University of Ghana, Accra, Ghana.
¹⁴ Center for Translational and International Hematology, Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, USA.
¹⁵ Department of Medicine and Center for Genomic and Precision Medicine, University of Ibadan, Ibadan, Nigeria.
¹⁶ Department of Public Health Sciences, Loyola University Chicago, Maywood, IL, USA.
¹⁷ Division of Biostatistics and Bioinformatics, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, USA.
¹⁸ Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, USA. sadebamowo@som.umaryland.edu.
¹⁹ University of Maryland Marlene and Stewart Greenbaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, MD, USA. sadebamowo@som.umaryland.edu.

PMID: 35513726
PMCID: PMC9907721
DOI: 10.1038/s41588-022-01074-3

Abstract

The Cardiometabolic Disorders in African-Ancestry Populations (CARDINAL) study site is a well-powered, first-of-its-kind resource for developing, refining and validating methods for research into polygenic risk scores that accounts for local ancestry, to improve risk prediction in diverse populations.

PubMed Disclaimer

Conflict of interest statement

Competing interests

The authors declare no conflict of interest. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscripts.

Figures

**Fig. 1 |. Ancestry distribution in GWAS.**
This figure summarizes the distribution of ancestry data contained in the GWAS catalog for studies published from March 2005 to January 2022. It shows the distribution of ancestry categories in percentages, of individuals over time from studies indicating one broad ancestry group. NR, not reported; SSA, sub-Saharan Africa. The figure was created with data obtained from the GWAS catalog.

**Fig. 2 |. Geographic representation of the core cohorts.**
Red indicates the regions where study participants were recruited into the core cohorts in CARDINAL. The figure was created using ArcGIS Pro software by Esri (https://www.esri.com/en-us/arcgis/products/arcgis-pro/overview).

See this image and copyright information in PMC

References

1. Diseases, G. B. D. & Injuries, C. Lancet 396, 1204–1222 (2020). - PMC - PubMed
1. Adebamowo SN, Tekola-Ayele F, Adeyemo AA & Rotimi CN Public Health Genomics 20, 9–26 (2017). - PubMed
1. Dikilitas O et al. Am. J. Hum. Genet 106, 707–716 (2020). - PMC - PubMed
1. Wuttke M et al. Nat. Genet 51, 957–972 (2019). - PMC - PubMed
1. Levy D et al. Nat. Genet 41, 677–687 (2009). - PMC - PubMed

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions

Grants and funding

LinkOut - more resources

Full Text Sources

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Polygenic risk scores for CARDINAL study

Affiliations

Polygenic risk scores for CARDINAL study

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources