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Observational Study
. 2022 May 6;20(1):144.
doi: 10.1186/s12957-022-02606-1.

The role of systemic immuno-inflammatory factors in resectable pancreatic adenocarcinoma: a cohort retrospective study

D Schlanger  1   2 , C Popa  3   4 , S Pașca  5 , A Seicean  1   6 , N Al Hajjar  1   2
Affiliations
Observational Study

The role of systemic immuno-inflammatory factors in resectable pancreatic adenocarcinoma: a cohort retrospective study

D Schlanger et al. World J Surg Oncol. .

Abstract

Background: Pancreatic cancer is an aggressive malignancy, surgery being the only potentially curative treatment. The systemic inflammatory response is an important factor in the development of cancer. There is still controversy regarding its role in pancreatic cancer.

Methods: Our study is a retrospective observational cohort study. We included patients diagnosed with pancreatic ductal adenocarcinoma (PDAC), who underwent surgical resection in our hospital, between January 2012 and December 2019. We gathered information from preoperative and postoperative blood tests. Neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), lymphocyte to monocyte ratio (LMR), prognostic nutritional index (PNI) and systemic immune-inflammation index (SII) were determined.

Results: We included 312 patients. All the immune-inflammatory scores assessed significantly changed after the surgery. The impact on overall survival of these markers showed that only some of the postoperative scores predicted survival: high PLR had a negative prognostic impact, while high lymphocyte and PNI values had a positive effect on overall survival.

Discussion: The circulating immune cells and their values integrated in the assessed prognostic scores suffer statistically significant changes after curative pancreatic surgery. Only the postoperative values of lymphocyte count, PLR, and PNI seem to influence the overall survival in PDAC.

Trial registration: ClinicalTrials.gov-identifier NCT05025371 .

Keywords: Cancer prognosis; Pancreatic cancer; Platelet to lymphocyte ratio; Prognostic nutritional index; Systemic inflammatory response.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Kaplan-Meier curves showing the association of postoperative lymphocyte count, PLR, and PNI on overall survival
See this image and copyright information in PMC

References

    1. Haeberle L, Esposito I. Pathology of pancreatic cancer. Transl Gastroenterol Hepatol. 2019;4:50. doi: 10.21037/tgh.2019.06.02. - DOI - PMC - PubMed
    1. Ducreux M, Cuhna AS, Caramella C, Hollebecque A, Burtin P, Goéré D, et al. Cancer of the pancreas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2015;26:v56–v68. doi: 10.1093/annonc/mdv295. - DOI - PubMed
    1. Lambert A, Schwarz L, Borbath I, Henry A, van Laethem J-L, Malka D, et al. An update on treatment options for pancreatic adenocarcinoma. Ther Adv Med Oncol. 2019;11:1758835919875568. doi: 10.1177/1758835919875568. - DOI - PMC - PubMed
    1. Harris M, Brekke M, Dinant G-J, Esteva M, Hoffman R, Marzo-Castillejo M, et al. Primary care practitioners’ diagnostic action when the patient may have cancer: an exploratory vignette study in 20 European countries. BMJ Open. 2020;10:e035678. doi: 10.1136/bmjopen-2019-035678. - DOI - PMC - PubMed
    1. Proctor MJ, Morrison DS, Talwar D, Balmer SM, Fletcher CD, O’Reilly DS, et al. A comparison of inflammation-based prognostic scores in patients with cancer. A Glasgow Inflammation Outcome Study. Eur J Cancer. 2011;47:2633–2641. doi: 10.1016/j.ejca.2011.03.028. - DOI - PubMed

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