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. 2022 Jul;28(7):1512-1515.
doi: 10.3201/eid2807.220467. Epub 2022 May 6.

Persistent SARS-CoV-2 Alpha Variant Infection in Immunosuppressed Patient, France, February 2022

Slim Fourati, Guillaume Gautier, Myriam Chovelon, Alexandre Soulier, Melissa N'Debi, Vanessa Demontant, Céline Kennel, Christophe Rodriguez, Jean-Michel Pawlotsky

Persistent SARS-CoV-2 Alpha Variant Infection in Immunosuppressed Patient, France, February 2022

Slim Fourati et al. Emerg Infect Dis. 2022 Jul.

Abstract

We describe persistent circulation of SARS-CoV-2 Alpha variant in an immunosuppressed patient in France during February 2022. The virus had a new pattern of mutation accumulation. The ongoing circulation of previous variants of concern could lead to reemergence of variants with the potential to propagate future waves of infection.

Keywords: Alpha variant; COVID-19; France; SARS; SARS-CoV-2; coronavirus; coronavirus disease; mutations; respiratory infections; severe acute respiratory syndrome coronavirus 2; viruses; zoonoses.

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Figures

Figure
Figure
Timeline of SARS-CoV-2 diagnostic tests, hospitalizations, booster vaccination, and treatments for an immunosuppressed patient with persistent SARS-CoV-2 Alpha variant infection, France, 2022. RCHOP, combination therapy of rituximab, cyclophosphamide, doxorubicine, vincristine, and prednisone; RDHAC, combination therapy of rituximab, cytarabine, dexamethasone, and carboplatine.
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