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. 2020 Jun 9;10(37):22058-22079.
doi: 10.1039/d0ra04290k. eCollection 2020 Jun 8.

Natural product diversity from the endophytic fungi of the genus Aspergillus

Seham S El-Hawary  1 , Abeer S Moawad  2 , Hebatallah S Bahr  3 , Usama Ramadan Abdelmohsen  4   5 , Rabab Mohammed  2
Affiliations

Natural product diversity from the endophytic fungi of the genus Aspergillus

Seham S El-Hawary et al. RSC Adv. .

Abstract

The endophytic fungus Aspergillus is considered as an enormous source of chemical leads with promising biological activities. Different Aspergillus species have proved their ability to produce plenty of secondary metabolites including butenolides, alkaloids, terpenoids, cytochalasins, phenalenones, ρ-terphenyls, xanthones, sterols, diphenyl ether and anthraquinone derivatives with diverse biological activities, such as anti-cancer, antifungal, anti-bacterial, anti-viral, anti-inflammatory, antitrypanosomal and antileishmanial activities. From January 2015 until December 2019, three hundred and sixty-one secondary metabolites were reported from different endophytic Aspergillus species. This review discusses the isolated secondary metabolites from different endophytic Aspergillus species reported from January 2015 to December 2019 along with their reported biological activities and structural aspects whenever applicable.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Fig. 1
Fig. 1. Chemical structure of compounds 1–6.
Fig. 2
Fig. 2. Chemical structure of compounds 7–15.
Fig. 3
Fig. 3. Chemical structure of compounds 16–24.
Fig. 4
Fig. 4. Chemical structure of compounds 25–34.
Fig. 5
Fig. 5. Chemical structure of compounds 35–43.
Fig. 6
Fig. 6. Chemical structure of compounds 44–57.
Fig. 7
Fig. 7. Chemical structure of compounds 58–63.
Fig. 8
Fig. 8. Chemical structure of compounds 64–69.
Fig. 9
Fig. 9. Chemical structure of compounds 70–76.
Fig. 10
Fig. 10. Chemical structure of compounds 77–81.
Fig. 11
Fig. 11. Chemical structure of compounds 82–86.
Fig. 12
Fig. 12. Chemical structure of compounds 87–93.
Fig. 13
Fig. 13. Chemical structure of compounds 94–99.
Fig. 14
Fig. 14. Chemical structure of compounds 100–105.
Fig. 15
Fig. 15. Chemical structure of compounds 106–114.
Fig. 16
Fig. 16. Chemical structure of compounds 115–121.
Fig. 17
Fig. 17. Chemical structure of compounds 122–127.
Fig. 18
Fig. 18. Chemical structure of compounds 128–130.
Fig. 19
Fig. 19. Chemical structure of compounds 131–136.
Fig. 20
Fig. 20. Chemical structure of compounds 137–144.
Fig. 21
Fig. 21. Chemical structure of compounds 145–153.
Fig. 22
Fig. 22. Chemical structure of compounds 154–163.
Fig. 23
Fig. 23. Chemical structure of compounds 164–167.
Fig. 24
Fig. 24. Chemical structure of compounds 168–173.
Fig. 25
Fig. 25. Chemical structure of compounds 174–178.
Fig. 26
Fig. 26. Chemical structure of compounds 179–187.
Fig. 27
Fig. 27. Secondary metabolites from Aspergillus endophytes.
Fig. 28
Fig. 28. Percentage of secondary metabolites from Aspergillus endophytes 2015–2019.
Fig. 29
Fig. 29. Percentage distribution of secondary metabolites from Aspergillus endophytes.
See this image and copyright information in PMC

References

    1. Soltani J., New Futur. Dev. Microb. Biotechnol. Bioeng., Elseiver, 2016, pp. 275–292
    1. Nisa H. Kamili A. N. Nawchoo I. A. Sha S. Shameem N. Bandh S. A. Microb. Pathog. 2015;82:50–59. doi: 10.1016/j.micpath.2015.04.001. - DOI - PubMed
    1. Gutierrez R. M. P. Gonzalez A. M. N. Ramirez A. M. Curr. Med. Chem. 2012;19:2992–3030. doi: 10.2174/092986712800672111. - DOI - PubMed
    1. Sadorn K. Saepua S. Boonyuen N. Laksanacharoen P. Rachtawee P. Prabpai S. Kongsaeree P. Pittayakhajonwut P. Tetrahedron. 2016;72:489–495. doi: 10.1016/j.tet.2015.11.056. - DOI
    1. Vadlapudi V. Borah N. Yellusani K. R. Gade S. Reddy P. Rajamanikyam M. Vempati L. N. S. Gubbala S. P. Chopra P. Upadhyayula S. M. Amanchy R. Sci. Rep. 2017;7:1–10. doi: 10.1038/s41598-016-0028-x. - DOI - PMC - PubMed