Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Apr;11(4):1489-1492.
doi: 10.4103/jfmpc.jfmpc_1409_21. Epub 2022 Mar 18.

Assessment of pre and post donation changes in hematological parameters and serum calcium and magnesium levels in plateletpheresis donors

Neha Syal  1 , Neetu Kukar  2 , Harkiran Arora  3 , Arunpreet Kaur  4 , Anjali Handa  2 , R N Maharishi  5
Affiliations

Assessment of pre and post donation changes in hematological parameters and serum calcium and magnesium levels in plateletpheresis donors

Neha Syal et al. J Family Med Prim Care. 2022 Apr.

Abstract

Background: Single donor platelet products are preferred over random donor platelet products due to several advantages. However, safety issues with regard to post procedure hematological decrements and serum calcium and magnesium levels in donors undergoing plateletpheresis have been explored minimally.

Aims: This prospective study was done to analyze the effects of plateletpheresis on donor's hematological parameters and serum calcium and magnesium levels.

Settings and design: It is a prospective, cross-sectional study conducted in the department of immunohematology and blood transfusion.

Material and methods: This study was undertaken on 150 healthy plateletpheresis donors over a period of 1 year. Blood samples were collected from each donor before and after the procedure, one in ethylenediaminetetraacetic acid (EDTA) vial for estimation of hematological parameters and another in plain vial for serum calcium and magnesium levels.

Statistical analysis used: Paired t-test was used to analyze the data.

Results: This study included donors in the age group of 18 to 60 years who underwent plateletpheresis on Haemonetics model of a machine (MCS) + intermittent flow cell separator. A statistically significant increase was observed in mean post procedural Hb (0.95%), Hct (0.7%), and red blood cell (RBC) count (1.3%). There was a decrease in mean post procedural platelet count (27.5%), white blood cell (WBC) count (4.02%), mean serum calcium (1.5%), and serum magnesium (5.1%), which was statistically highly significant (P < 0.001). No significant change was observed in post procedural mean platelet volume (MPV) and platelet distribution width (PDW).

Conclusion: Amid the need of increased demand for plateletpheresis, donor safety must be ensured. Failing to do so can be detrimental to blood supply chain, hence stringent programs for post donation screening of plateletpheresis donors need to be established.

Keywords: Cell separators; hematological parameters; plateletpheresis; serum calcium and magnesium.

PubMed Disclaimer

Conflict of interest statement

There are no conflicts of interest.

Figures

Graph 1
Graph 1
Comparison of pre and post donation changes in Hemoglobin, WBC count, Serum calcium and magnesium levels in plateletpheresis donors
Flowchart 1
Flowchart 1
Summary of the study
See this image and copyright information in PMC

References

    1. Freireich EJ. Origins of platelet transfusion therapy. Transfuse Med Rev. 2011;25:252–6. - PubMed
    1. Ness PM, Lee C, Sally A. Single donor versus pooled random donor platelet concentrates. Transfusion. 2001;8:392–96. - PubMed
    1. Gite V, Dhakane M. Analysis of pre and post donation haematological values in plateletpheresis donors. Apollo Med. 2015;12:123–5. - PubMed
    1. Glicher RO, Smith JW. Apheresis principles and technology of Hemapheresis. In: Simon TL, Synder EL, Solheim BG, Stowell CP, Strauss RG, Petrides M, editors. Rossi's Principles of Transfusion Medicine. 4th ed. Wiley Blackwell; 2009. p. 624.
    1. Hartwell BA, Eastvold PJ. Apheresis. In: Harmening DM, editor. Modern Blood Banking and Transfusion Practices. 6th ed. New Delhi: Jaypee Brothers Medical publishers; 2012. pp. 346–7.