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. 2020 Jul 2;10(42):25165-25169.
doi: 10.1039/d0ra05217e. eCollection 2020 Jun 29.

Iodine-catalyzed efficient synthesis of xanthene/thioxanthene-indole derivatives under mild conditions

Weihang Miao  1 , Pingting Ye  1 , Mengjiao Bai  1 , Zhixin Yang  1 , Suyue Duan  1 , Hengpan Duan  2 , Xuequan Wang  1
Affiliations

Iodine-catalyzed efficient synthesis of xanthene/thioxanthene-indole derivatives under mild conditions

Weihang Miao et al. RSC Adv. .

Abstract

An iodine-catalyzed nucleophilic substitution reaction of xanthen-9-ol and thioxanthen-9-ol with indoles has been developed, providing an efficient procedure for the synthesis of xanthene/thioxanthene-indole derivatives with good to excellent yields. This protocol offers several advantages, such as short reaction times, green solvent, operational simplicity, easily available catalyst and mild reaction conditions. Moreover, this method showed good tolerance of functional groups and a wide range of substrates.

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Conflict of interest statement

There are no conflicts to declare.

Figures

Scheme 1
Scheme 1. I2-catalyzed synthesis of xanthene/thioxanthene-indole derivatives.
Scheme 2
Scheme 2. Control experiments.
Scheme 3
Scheme 3. Proposed mechanisms.
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