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. 2020 Jun 30;10(42):24795-24799.
doi: 10.1039/d0ra03966g. eCollection 2020 Jun 29.

Synthesis of 2,5-diaryloxazoles through rhodium-catalyzed annulation of triazoles and aldehydes

Jian Li  1 , Shang-Rong Zhu  1 , Yue Xu  1 , Xue-Chen Lu  1 , Zheng-Bing Wang  1 , Li Liu  1 , De-Feng Xu  1
Affiliations

Synthesis of 2,5-diaryloxazoles through rhodium-catalyzed annulation of triazoles and aldehydes

Jian Li et al. RSC Adv. .

Abstract

An efficient synthesis of a variety of 2,5-diaryloxazole derivatives via a rhodium-catalyzed annulation of triazoles and aldehydes is achieved. Various oxazole derivatives could be obtained in good to excellent yields. A concise synthesis of antimycobaterial natural products balsoxin and texamine has been achieved using this method.

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Conflict of interest statement

There are no conflicts to declare.

Figures

Scheme 1
Scheme 1. Selected synthetic strategies for 2,5-disubstituted oxazoles.
Scheme 2
Scheme 2. Reactions between N-sulfonyl 1,2,3-triazoles and nitriles/aldehydes.
Scheme 3
Scheme 3. One-step synthesis of natural products.
Scheme 4
Scheme 4. Possible mechanistic pathways.
See this image and copyright information in PMC

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