Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Jan 8;9(2):844-852.
doi: 10.1039/c8ra07533f. eCollection 2019 Jan 2.

Applications of self-assembling ultrashort peptides in bionanotechnology

Ming Ni  1   2 , Shuangmu Zhuo  1
Affiliations
Review

Applications of self-assembling ultrashort peptides in bionanotechnology

Ming Ni et al. RSC Adv. .

Abstract

Peptides are intriguing building blocks for a variety of applications in bionanotechnology. Peptides can self-assemble into well-ordered nanostructures. Among the various nanomorphology forms, peptide nanofibers and nanotubes are relevant in biomedical applications. In this review, their applications as tissue engineering scaffolds, drug delivery vehicles, three-dimensional printing bioinks and bioimaging nanoprobes will be illustrated. This review article describes di-, tri-, tetra-peptides because they are cost-effective, simple to prepare, and amenable to production on a large scale.

PubMed Disclaimer

Conflict of interest statement

There are no conflicts to declare.

Figures

Fig. 1
Fig. 1. Different peptide nanostructures.
Fig. 2
Fig. 2. Ultrashort peptide applications in bionanotechnology.
Fig. 3
Fig. 3. The chemical structure of ΔF.
Fig. 4
Fig. 4. Schematic illustration of an experimental set-up showing peptide nanoparticles with fat tissue from a rat, sandwiched between glass slides (left). 3D image of the peptide nanoparticles as a SHG z-stack (right). Figure reproduced from ref. 10. Copyright 2016 IOP Publishing.
None
Ming N
None
Shuangmu Zhuo
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Ni M. and Hauser C. A. E., Self-Assembled Peptide Nanostructures for Regenerative Medicine and Biology, in Micro and Nanofabrication Using SelfAssembled Biological Nanostructures, ed. J. C.-L. E. Svendsen, William Andrew Publishing, Oxford, 2015, Ch. 4, pp. 63–90
    1. Cui H. Muraoka T. Cheetham A. G. Stupp S. I. Self-assembly of giant peptide nanobelts. Nano Lett. 2009;9:945–951. doi: 10.1021/nl802813f. - DOI - PMC - PubMed
    1. Khoe U. Yang Y. Zhang S. Self-assembly of nanodonut structure from a cone-shaped designer lipid-like peptide surfactant. Langmuir. 2009;25:4111–4114. doi: 10.1021/la8025232. - DOI - PubMed
    1. Wagner D. E. Phillips C. L. Ali W. M. Nybakken G. E. Crawford E. D. Schwab A. D. et al. Toward the development of peptide nanofilaments and nanoropes as smart materials. Proc. Natl. Acad. Sci. U. S. A. 2005;102:12656–12661. doi: 10.1073/pnas.0505871102. - DOI - PMC - PubMed
    1. Orbach R. Adler-Abramovich L. Zigerson S. Mironi-Harpaz I. Selikta D. Gazit E. Self-Assembled Fmoc-Peptides as a Platform for the Formation of Nanostructures and Hydrogels. Biomacromolecules. 2009;10:2646–2651. doi: 10.1021/bm900584m. - DOI - PubMed