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Review
. 2022 Apr 20:13:869950.
doi: 10.3389/fgene.2022.869950. eCollection 2022.

The Potential Role of m6A RNA Methylation in the Aging Process and Aging-Associated Diseases

Jin Sun  1   2 , Bokai Cheng  1   2 , Yongkang Su  1   2 , Man Li  1   2 , Shouyuan Ma  3 , Yan Zhang  4 , Anhang Zhang  1   2 , Shuang Cai  1   2 , Qiligeer Bao  1   2 , Shuxia Wang  1   2 , Ping Zhu  1   2
Affiliations
Review

The Potential Role of m6A RNA Methylation in the Aging Process and Aging-Associated Diseases

Jin Sun et al. Front Genet. .

Abstract

N6-methyladenosine (m6A) is the most common and conserved internal eukaryotic mRNA modification. m6A modification is a dynamic and reversible post-transcriptional regulatory modification, initiated by methylase and removed by RNA demethylase. m6A-binding proteins recognise the m6A modification to regulate gene expression. Recent studies have shown that altered m6A levels and abnormal regulator expression are crucial in the ageing process and the occurrence of age-related diseases. In this review, we summarise some key findings in the field of m6A modification in the ageing process and age-related diseases, including cell senescence, autophagy, inflammation, oxidative stress, DNA damage, tumours, neurodegenerative diseases, diabetes, and cardiovascular diseases (CVDs). We focused on the biological function and potential molecular mechanisms of m6A RNA methylation in ageing and age-related disease progression. We believe that m6A modification may provide a new target for anti-ageing therapies.

Keywords: N6-methyladenosine; RNA methylation; aging; aging-related disease; epigenetics.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Regulation of the m6A modification and the function of the m6A regulators.
See this image and copyright information in PMC

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