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. 2020 Oct 28;10(64):39067-39071.
doi: 10.1039/d0ra06563c. eCollection 2020 Oct 21.

A facile metal-free one-pot synthesis of 3-aminoisoquinolines by intramolecular transannulation of 1-sulfonyl-4-(2-aminomethylphenyl)-1,2,3-triazoles

Hai Shang  1   2 , Ling-Yu Li  1 , Yu Tian  1 , Hong-Mei Jia  1 , Zhong-Mei Zou  1
Affiliations

A facile metal-free one-pot synthesis of 3-aminoisoquinolines by intramolecular transannulation of 1-sulfonyl-4-(2-aminomethylphenyl)-1,2,3-triazoles

Hai Shang et al. RSC Adv. .

Abstract

A metal-free one-pot intramolecular transannulation of 1-sulfonyl-4-(2-aminomethylphenyl)-1,2,3-triazoles has been developed, which enables the facile synthesis of the various 3-aminoisoquinolines as well as relevant scaffolds from readily available starting materials.

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Conflict of interest statement

There are no conflicts to declare.

Figures

Fig. 1
Fig. 1. Background and our work.
Scheme 1
Scheme 1. Initial result of intramolecular annulation of 1-sulfonyl-4-(2-aminomethylphenyl)-1,2,3-triazoles.
Scheme 2
Scheme 2. Proposed mechanism of intramolecular annulation of 1-sulfonyl-4-(2-aminomethylphenyl)-1,2,3-triazoles.
See this image and copyright information in PMC

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