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. 2022 Apr 29:15:4475-4482.
doi: 10.2147/IJGM.S360834. eCollection 2022.

Acute Kidney Injury among Hospital-Admitted COVID-19 Patients: A Study from Jordan

Ashraf O Oweis  1 , Sameeha A Alshelleh  2 , Lubna Hawasly  3 , Ghalia Alsabbagh  3 , Karem H Alzoubi  4   5
Affiliations

Acute Kidney Injury among Hospital-Admitted COVID-19 Patients: A Study from Jordan

Ashraf O Oweis et al. Int J Gen Med. .

Abstract

Objective: During the COVID-19 pandemic, many patients have been admitted to hospitals with severe respiratory disease and suffered complications. Acute kidney injury (AKI) is among the more dangerous complications contributing to morbidity and mortality among patients.

Methods: This retrospective study focused on all hospital-admitted COVID-19 patients between September and December 2020. A total of 1,044 patients were enrolled. Patient demographics, medical records, and laboratory data were gathered. Patients were split into two groups: AKI and non-AKI. Comparisons comprised demographics, labs, ICU transfer, need for ventilation and oxygen therapy, medications, hospital stay, and deaths.

Results: AKI incidence in the cohort was 25.3%, and a majority were stage 1 (53.3%). Among these, hemodialysis was started in 1.8%. Higher age (P<0.001), diabetes mellitus (P=0.001), hypertension (P=0.001), ACEI/ARB use (P=0.008), erythrocyte-sedimentation rate (P=0.002), CRP (P<0.0001), and ferritin (P=0.01) were predictors of AKI. Among all admitted COVID-19 patients, 30.2% died in hospital. Among those with AKI, 75.9% died in comparison to 24.1% of non-AKI patients (P<0.001). Among COVID-19 patients admitted to the ICU, 80.5% died: 70.5% were from the AKI group and 29.5% from the non-AKI group (P<0.001).

Conclusion: High mortality and morbidity is associated with COVID-19 infection, and AKI is contributing significantly to the outcomes of hospitalized patients with the infection. Early recognition of and treatment for AKI will decrease mortality and hospitalization in patients with COVID-19.

Keywords: COVID; acute kidney injury; dialysis; mortality.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Pie chart of incidence of AKI stage based on AKIN stage.
Figure 2
Figure 2
Box plot of eGFR on admission and discharge based on AKI status.
Figure 3
Figure 3
Kaplan–Meier survival curve of survival probability by time of discharge based on AKI status.
See this image and copyright information in PMC

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References

    1. Wonnacott A, Meran S, Amphlett B, Talabani B, Phillips A. Epidemiology and outcomes in community-acquired versus hospital-acquired AKI. Clin J Am Soc Nephrol. 2014;9(6):1007–1014. doi:10.2215/CJN.07920713 - DOI - PMC - PubMed
    1. Santos RPD, Carvalho ARS, Peres LAB, Ronco C, Macedo E. An epidemiologic overview of acute kidney injury in intensive care units. AMB Rev Assoc Med Bras. 2019;65(8):1094–1101. doi:10.1590/1806-9282.65.8.1094 - DOI - PubMed
    1. Pinheiro KHE, Azedo FA, Areco KCN, Laranja SMR. Risk factors and mortality in patients with sepsis, septic and non septic acute kidney injury in ICU. J Bras Nefrol. 2019;41:462–471. doi:10.1590/2175-8239-jbn-2018-0240 - DOI - PMC - PubMed
    1. Jiang L, Zhu Y, Luo X, et al. Epidemiology of acute kidney injury in intensive care units in Beijing: the multi-center BAKIT study. BMC Nephrol. 2019;20(1):468. doi:10.1186/s12882-019-1660-z - DOI - PMC - PubMed
    1. Ahmed AR, Obilana A, Lappin D. Renal replacement therapy in the critical care setting. Crit Care Res Pract. 2019;2019:6948710. doi:10.1155/2019/6948710 - DOI - PMC - PubMed