Probiotics in Critically Ill Patients: An Umbrella Review

doi:10.5005/jp-journals-10071-24129

. 2022 Mar;26(3):339-360.

doi: 10.5005/jp-journals-10071-24129.

Probiotics in Critically Ill Patients: An Umbrella Review

Amirreza Naseri¹, Sepideh Seyedi-Sahebari¹, Ata Mahmoodpoor², Sarvin Sanaie³

Affiliations

¹ Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; Research Center for Evidence-based-Medicine, Iranian EBM Center: A Joanna Briggs Institute (JBI) Center of Excellence, Tabriz University of Medical Sciences, Tabriz, Iran.
² Department of Anesthesiology and Critical Care, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
³ Research Center for Integrative Medicine in Aging, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran.

PMID: 35519905
PMCID: PMC9015916
DOI: 10.5005/jp-journals-10071-24129

Probiotics in Critically Ill Patients: An Umbrella Review

Amirreza Naseri et al. Indian J Crit Care Med. 2022 Mar.

. 2022 Mar;26(3):339-360.

doi: 10.5005/jp-journals-10071-24129.

Authors

Amirreza Naseri¹, Sepideh Seyedi-Sahebari¹, Ata Mahmoodpoor², Sarvin Sanaie³

Affiliations

¹ Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran; Research Center for Evidence-based-Medicine, Iranian EBM Center: A Joanna Briggs Institute (JBI) Center of Excellence, Tabriz University of Medical Sciences, Tabriz, Iran.
² Department of Anesthesiology and Critical Care, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
³ Research Center for Integrative Medicine in Aging, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran.

PMID: 35519905
PMCID: PMC9015916
DOI: 10.5005/jp-journals-10071-24129

Abstract

Objectives: Probiotics are live microorganisms which when administered in adequate amounts confer a health benefit on the host. Because of the wide usage of antibiotics, acute changes in diet, and the stress of illness, critically ill patients' homeostasis of the gut microbiome can be disrupted during intensive care unit (ICU) confinement; probiotics are suggested as a beneficial intervention in critically ill patients. We tried to give an overview of the effects of probiotic supplements in critically ill patients based on published systematic reviews (SRs) and meta-analyses (MAs).

Data sources: A systematic search was performed in four databases as well as hand searching.

Study selection: The results were independently screened in two title/abstracts and full-text stages.

Data extraction: Any reported outcomes in each study were extracted, using a data extraction table.

Data synthesis: A wide range of outcomes of using probiotic supplements in critically ill patients have been reported in 20 included studies. Based on the current knowledge, we can say that probiotics may reduce the rate of ventilator-associated pneumonia, nosocomial pneumonia, the overall infection rate, duration of mechanical ventilation, and antibiotic use in critically ill patients, but there is not a significant association between using the probiotics and mortality, length of hospitalization, and incidence of diarrhea.

Conclusion: Despite the various beneficial effects of probiotics in critically ill patients, there is not yet much evidence supporting the routine use of these supplements and further well-designed multicenter trials are needed to provide "evidence-based" recommendations.

How to cite this article: Naseri A, Seyedi-Sahebari S, Mahmoodpoor A, Sanaie S. Probiotics in Critically Ill Patients: An Umbrella Review. Indian J Crit Care Med 2022;26(3):339-360.

Keywords: Critical illness; Intensive care units; Probiotics; Systematic review; Umbrella review.

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Conflict of interest statement

Source of support: This work was supported by Deputy for Research of Tabriz University of Medical Sciences. Conflict of interest: None

Figures

**Fig. 1**
Summary of the risk of bias assessment based on ROBIS tool. P, phase; D, domain; Q, question

See this image and copyright information in PMC

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References

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1. McFarland LV, Evans CT, Goldstein EJ. Strain-specificity and disease specificity of probiotic efficacy: a systematic review and meta-analysis. Front Med. 2018;5:124. doi: 10.3389/fmed.2018.00124. - DOI - PMC - PubMed
1. Manzhalii E, Virchenko O, Falalyeyeva T, Beregova T, Stremmel W. Treatment efficacy of a probiotic preparation for non-alcoholic steatohepatitis: a pilot trial. J Dig Dis. 2017;18(12):698–703. doi: 10.1111/1751-2980.12561. - DOI - PubMed
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[1] Tewari S, David J, Gautam A. A review on probiotic dairy products and digestive health. J Pharmacogn Phytochem. 2019;8(3):368–372. https://www.phytojournal.com/archives/2019/vol8issue3/PartH/8-3-57-432.pdf Available from:

[2] Tewari S, David J, Gautam A. A review on probiotic dairy products and digestive health. J Pharmacogn Phytochem. 2019;8(3):368–372. https://www.phytojournal.com/archives/2019/vol8issue3/PartH/8-3-57-432.pdf Available from:

[3] FAO/WHO J. Report of a Joint FAO/WHO Working Group on drafting guidelines for the evaluation of probiotics in food. London, Ontario, Canada. Apr 30, May 30, 2002. and. Available from: http://whoint/foodsafety/fs_management/en/probiotic_guidelinespdf.

[4] FAO/WHO J. Report of a Joint FAO/WHO Working Group on drafting guidelines for the evaluation of probiotics in food. London, Ontario, Canada. Apr 30, May 30, 2002. and. Available from: http://whoint/foodsafety/fs_management/en/probiotic_guidelinespdf.

[5] McFarland LV, Evans CT, Goldstein EJ. Strain-specificity and disease specificity of probiotic efficacy: a systematic review and meta-analysis. Front Med. 2018;5:124. doi: 10.3389/fmed.2018.00124. - DOI - PMC - PubMed

[6] McFarland LV, Evans CT, Goldstein EJ. Strain-specificity and disease specificity of probiotic efficacy: a systematic review and meta-analysis. Front Med. 2018;5:124. doi: 10.3389/fmed.2018.00124. - DOI - PMC - PubMed

[7] Manzhalii E, Virchenko O, Falalyeyeva T, Beregova T, Stremmel W. Treatment efficacy of a probiotic preparation for non-alcoholic steatohepatitis: a pilot trial. J Dig Dis. 2017;18(12):698–703. doi: 10.1111/1751-2980.12561. - DOI - PubMed

[8] Manzhalii E, Virchenko O, Falalyeyeva T, Beregova T, Stremmel W. Treatment efficacy of a probiotic preparation for non-alcoholic steatohepatitis: a pilot trial. J Dig Dis. 2017;18(12):698–703. doi: 10.1111/1751-2980.12561. - DOI - PubMed

[9] Liang D, Longgui N, Guoqiang X. Efficacy of different probiotic protocols in irritable bowel syndrome: a network meta-analysis. Medicine. 2019;98(27):e16068. doi: 10.1097/MD.0000000000016068. - DOI - PMC - PubMed

[10] Liang D, Longgui N, Guoqiang X. Efficacy of different probiotic protocols in irritable bowel syndrome: a network meta-analysis. Medicine. 2019;98(27):e16068. doi: 10.1097/MD.0000000000016068. - DOI - PMC - PubMed

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Probiotics in Critically Ill Patients: An Umbrella Review

Affiliations

Probiotics in Critically Ill Patients: An Umbrella Review

Authors

Affiliations

Abstract

Conflict of interest statement

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