Gelatin methacryloyl (GelMA)-based biomaterials for bone regeneration

Abstract

Gelatin methacryloyl (GelMA)-based biomaterials have been widely used in various biomedical applications due to their suitable biological properties and tuneable physical characteristics. In particular, GelMA can be used as a versatile matrix for bone tissue engineering scaffolds via various strategies to overcome major obstacles such as insufficient mechanical property and uncontrollable degradation. This review presents the research status of GelMA, its structure and function, GelMA-based biomaterials and the development of methods along with their existing challenges.

Fig. 1. Schematic of GelMA and the fabrication of its hydrogels.

Fig. 2. Fabrication of the bone mimetic 3D architecture using the 3D bioprinted method to construct a bone-like unite architecture.

Fig. 3. Fabrication of the bone mimetic 3D architecture using the micromachining method to construct osteogenic and vasculogenic niches.

Fig. 4. The application of the micromachining method for the engineering of hydrogels to create 3D vascularized bone tissues.

Zhipeng Gu