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. 2022 Apr 25:27:100315.
doi: 10.1016/j.jctube.2022.100315. eCollection 2022 May.

Proportion and trend of primary resistance among Multidrug resistant Tuberculosis patients in Ethiopia

Adamu Bayissa  1 , Meaza Demissie  2 , Mulatu Biru  1 , Zenebe Akalu  1
Affiliations

Proportion and trend of primary resistance among Multidrug resistant Tuberculosis patients in Ethiopia

Adamu Bayissa et al. J Clin Tuberc Other Mycobact Dis. .

Abstract

Background: Evidence based information on the proportion & trend of primary resistance among multidrug resistance (MDR) TB patients is important for designing effective strategies in the control of the disease.

Methods: A retrospective record review of 348 MDR/RR-TB patients treated at All African Leprosy Rehabilitation & Training (ALERT) Center from January 2014- December 2018. Categorical variables were compared using Chi-square/Fisher exact test as appropriate. Trend analysis was done using chi-square & linear regression. Logistic regression analysis was done to determine the factors associated with primary MDR/RR TB. Adjusted Odds Ratio (AOR) with 95% CI and p value < 5% were used to report factors associated.

Result: Proportion of primary resistance among MDR/RR TB patients was 25.9% with 95% CI 21.3-30.3%. The proportion increased form 9.7% in 2014 to 43.4% in 2018 at a yearly increasing rate of 9.27%. Contact history to TB patient & year of diagnosis 2017 and 2018 were significantly associated with primary resistance AOR (95% CI) & p value 4.15(1.75-9.84) p = 0.001, 3.87(1.44-10.39) p = 0.007, 3.43(1.20-9.84) p = 0.022 respectively.

Conclusion: The study revealed a high proportion of primary resistance among MDR/RR TB during the study period with a linearly increasing fashion thus a need for due attention in the efforts to control MDR TB.

Keywords: Multidrug resistance TB; Primary drug resistance TB; Risk factors for drug resistance TB.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Annual number of MDR/RR Pulmonary TB patients age ≥15 years treated at ALERT Center 2014–2018.
Fig. 2
Fig. 2
Trend for Proportion of Primary Resistance among Pulmonary MDR/RR TB patients age ≥15 years treated at ALERT Center 2014–2018.
See this image and copyright information in PMC

References

    1. Ba Diallo A., Ossoga G.W., Daneau G., Lo S., Ngandolo R., Djaibé C.D., et al. Emergence and clonal transmission of multi-drug-resistant tuberculosis among patients in Chad. BMC Infect Dis. 2017;17(1) - PMC - PubMed
    1. Khatua S., Geltemeyer A.M., Gourishankar A. Tuberculosis: Is the landscape changing? Pediatr Res. 2017;81(1–2):265–270. - PubMed
    1. Mathuria J.P., Samaria J.K., Srivastava G.N., Mathuria B.L., Ojha S.K., Anupurba S. Primary and acquired drug resistance patterns of Mycobacterium tuberculosis isolates in India: a multicenter study. J Infect Public Health. 2013;6(6):456–464. - PubMed
    1. GLOBAL TUBERCULOSIS REPORT 2017. GENEVA: WORLD HEALTH ORGANIGATION, 2017. Licence CC BY-NC-SA 3.0 1GO.
    1. Abate D., Taye B., Abseno M., Biadgilign S. Epidemiology of anti-tuberculosis drug resistance patterns and trends in tuberculosis referral hospital in Addis Ababa, Ethiopia. BMC Res Notes. 2012;5:462. - PMC - PubMed

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