Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Apr 26:2022:1119038.
doi: 10.1155/2022/1119038. eCollection 2022.

Diagnostic Accuracy of Salivary Biomarkers including Lactate Dehydrogenase and Hemoglobin A1c for Screening Chronic Periodontitis

Somaye Ansari Moghadam  1 , Fateme Soude Ahmadi Moghadam  2 , Ebrahim Alijani  3
Affiliations

Diagnostic Accuracy of Salivary Biomarkers including Lactate Dehydrogenase and Hemoglobin A1c for Screening Chronic Periodontitis

Somaye Ansari Moghadam et al. Dis Markers. .

Abstract

Aims: Periodontitis is one of the most common chronic bacterial infections in humans involving the tooth-supporting tissue. The present study aimed to evaluate and compare salivary biomarkers, including lactate dehydrogenase (LDH) and hemoglobin A1c (HbA1c), between patients with severe chronic periodontitis and healthy individuals. Methods: This study was performed on 29 patients with severe chronic periodontitis and 30 healthy individuals at Zahedan University of Medical Sciences, Zahedan, Iran, in 2021. Salivary samples were taken, and clinical parameters, including the clinical attachment loss (CAL) and probing pocket depth (PPD), were measured. Besides, the levels of LDH and HbA1c were measured using ELISA kits. The sensitivity, specificity, and positive and negative predictive values of HbA1c and LDH were examined for chronic periodontitis diagnosis. Results: Based on the present results, the levels of LDH and HbA1C did not show adequate sensitivity or specificity for screening chronic periodontitis. Conclusion: According to the present findings, salivary biomarkers, including LDH and HbA1c, cannot be used with certainty for screening chronic periodontitis.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
Diagnostic flowchart for screening periodontal disease with level HbA1c and LDH saliva (CPI = 3) as the main cutoff is considered and DH (272), HbA1c (257) cutoff lines is calculated based on it.
Figure 2
Figure 2
ROC curve for HbA1c and LDH diagnostic value for periodontal disease assessment.
See this image and copyright information in PMC

References

    1. Su F., Liu S. S., Ma J. L., Wang D. S., Ll E., Liu H. C. Enhancement of periodontal tissue regeneration by transplantation of osteoprotegerin-engineered periodontal ligament stem cells. Stem cell research & therapy . 2015;6(1) - PMC - PubMed
    1. Abdelhamid A. I. Effect of periodontal therapy using minocycline gel on gingival crevicular fluid osteoprotegerin in chronic periodontitis. Journal of American Science . 2012;8(7)
    1. Nam S. H., Jung H. I., Kang S. M., Inaba D., Kwon H. K., Kim B. I. Validity of screening methods for periodontitis using salivary hemoglobin level and self-report questionnaires in people with disabilities. Journal of periodontology. . 2015;86(4):536–545. doi: 10.1902/jop.2015.140457. - DOI - PubMed
    1. Nomura Y., Shimada Y., Hanada N., et al. Salivary biomarkers for predicting the progression of chronic periodontitis. Archives of oral biology. . 2012;57(4):413–420. doi: 10.1016/j.archoralbio.2011.09.011. - DOI - PubMed
    1. Hamodat H. F. “Taha MY,” Estimation of TNF-α and LDH in Chronic Periodontitis Patients in Mosul. International Journal of Sciences: Basic and Applied Research . 2020;49(1):1–9.

LinkOut - more resources