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Review
. 2022 Dec;54(1):1202-1211.
doi: 10.1080/07853890.2022.2067897.

The East Africa Consortium for human papillomavirus and cervical cancer in women living with HIV/AIDS

Y Tong  1 , E Orang'o  2 , M Nakalembe  3 , P Tonui  2 , P Itsura  2 , K Muthoka  2 , M Titus  4 , S Kiptoo  2 , A Mwangi  2 , J Ong'echa  5 , R Tonui  2 , B Odongo  2 , C Mpamani  3 , B Rosen  6 , A Moormann  7 , S Cu-Uvin  8 , J A Bailey  8 , C I Oduor  8 , A Ermel  1 , C Yiannoutsos  1 , B Musick  1 , E Sang  9 , A Ngeresa  9 , G Banturaki  3 , A Kiragga  3 , J Zhang  10 , Y Song  10 , S Chintala  1 , R Katzenellenbogen  1 , P Loehrer  1 , D R Brown  1
Affiliations
Review

The East Africa Consortium for human papillomavirus and cervical cancer in women living with HIV/AIDS

Y Tong et al. Ann Med. 2022 Dec.

Abstract

The East Africa Consortium was formed to study the epidemiology of human papillomavirus (HPV) infections and cervical cancer and the influence of human immunodeficiency virus (HIV) infection on HPV and cervical cancer, and to encourage collaborations between researchers in North America and East African countries. To date, studies have led to a better understanding of the influence of HIV infection on the detection and persistence of oncogenic HPV, the effects of dietary aflatoxin on the persistence of HPV, the benefits of antiretroviral therapy on HPV persistence, and the differences in HPV detections among HIV-infected and HIV-uninfected women undergoing treatment for cervical dysplasia by either cryotherapy or LEEP. It will now be determined how HPV testing fits into cervical cancer screening programs in Kenya and Uganda, how aflatoxin influences immunological control of HIV, how HPV alters certain genes involved in the growth of tumours in HIV-infected women. Although there have been challenges in performing this research, with time, this work should help to reduce the burden of cervical cancer and other cancers related to HIV infection in people living in sub-Saharan Africa, as well as optimized processes to better facilitate research as well as patient autonomy and safety. KEY MESSAGESThe East Africa Consortium was formed to study the epidemiology of human papillomavirus (HPV) infections and cervical cancer and the influence of human immunodeficiency virus (HIV) infection on HPV and cervical cancer.Collaborations have been established between researchers in North America and East African countries for these studies.Studies have led to a better understanding of the influence of HIV infection on the detection and persistence of oncogenic HPV, the effects of dietary aflatoxin on HPV detection, the benefits of antiretroviral therapy on HPV persistence, and the differences in HPV detections among HIV-infected and HIV-uninfected women undergoing treatment for cervical dysplasia by either cryotherapy or LEEP.

Keywords: HIV; HPV; Kenya; Uganda; cervical cancer.

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Conflict of interest statement

Dr. Brown receives research funding from several sources including Merck and Co., Inc. Dr. Brown serves as a consultant for PDS, Inc.

References

    1. Inui TS, Nyandiko WM, Kimaiyo SN, et al. AMPATH: living proof that no one has to die from HIV. J Gen Intern Med. 2007;22(12):1745–1750. - PMC - PubMed
    1. Islami F, Torre LA, Drope JM, et al. Global cancer in women: cancer control priorities. Cancer Epidemiol Biomarkers Prev. 2017;26(4):458–470. - PubMed
    1. Mboumba Bouassa RS, Prazuck T, Lethu T, et al. Cervical cancer in Sub-Saharan Africa: an emerging and preventable disease associated with oncogenic human papillomavirus. Med Sante Trop. 2017;27(1):16–22. - PubMed
    1. Vaccarella S, Laversanne M, Ferlay J, et al. Cervical cancer in Africa, Latin America and the Caribbean and Asia: regional inequalities and changing trends. Int J Cancer. 2017;141(10):1997–2001. - PubMed
    1. Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424. - PubMed

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